The Role of the Floor Plate in Axon Guidance

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

1990 • 775 citations

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons

1988 • 739 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

Chemotropic guidance of developing axons in the mammalian central nervous system

1988 • 681 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

The Development of the Rat Spinal Cord

1984 • 513 citations

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans

1992 • 503 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

F-spondin: A gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension

1992 • 382 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Segmental homologies among reticulospinal neurons in the hindbrain of the zebrafish larva

1986 • 285 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant

1990 • 227 citations

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

1993 • 189 citations

Role of the floor plate in axonal patterning in the zebrafish CNS

1992 • 169 citations

Expression of S‐laminin and laminin in the developing rat central nervous system

1992 • 147 citations

The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth

1992 • 136 citations

Developmental changes in unique cell surface antigens of chick embryo spinal motoneurons and ganglion cells

1984 • 126 citations

Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).

1993 • 115 citations

Pathfinding by identified growth cones in the spinal cord of zebrafish embryos

1990 • 112 citations

Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline

1993 • 101 citations

Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos

1992 • 101 citations

Floor plate-derived signals and the control of neural cell pattern in vertebrates.

1990 • 100 citations

Central nervous system antigen P84 can serve as a substrate for neurite outgrowth

1990 • 100 citations

Identification of early developing axon projections from spinal interneurons in the chick embryo with a neuron specific β-tubulin antibody: evidence for a new ‘pioneer’ pathway in the spinal cord

1990 • 93 citations

Pathfinding by growth cones of commissural interneurons in the chick embryo spinal cord: A light and electron microscopic study

1991 • 90 citations

The extent of the floor‐plate of his and its significance

1920 • 75 citations

The development of the cervical spinal cord of the mouse embryo. II. A Golgi analysis of sensory, commissural, and association cell differentiation

1984 • 73 citations

Neurite outgrowth traced by means of horseradish peroxidase inherited from neuronal ancestral cells in frog embryos

1985 • 72 citations

The developmental significance of the floor‐plate of the brain and spinal cord

1930 • 69 citations

Do oculomotor neuroblasts migrate across the midline in the fetal rat brain?

1977 • 59 citations

Expression of a lacZ transgene reveals floor plate cell morphology and macromolecular transfer to commissural axons

1993 • 59 citations

An experimental analysis of in vivo guidance cues used by axons of spinal interneurons in the chick embryo: evidence for chemotropism and related guidance mechanisms

1991 • 53 citations

Growth pattern of pioneering chick spinal cord axons

1987 • 46 citations

Cell-cell interactions during the migration of an identified commissural growth cone in the embryonic grasshopper

1993 • 44 citations

Expression patterns of the cell adhesion molecule Nr-CAM during histogenesis of the chick nervous system

1993 • 43 citations

Early development of the rat precerebellar system: migratory routes, selective aggregation and neuritic differentiation of the inferior olive and lateral reticular nucleus neurons. An overview.

1990 • 32 citations

Expression of the F84.1 glycoprotein in the spinal cord and cranial nerves of the developing rat

1992 • 32 citations

Optic chiasm and infundibular decussation sites in the developing rat diencephalon are defined by Glial Raphes expressing p35 (Lipocortin 1, Annexin I)

1992 • 28 citations

Ultrastructural and cytochemical characterisation of the floor plate ependyma of the developing rat spinal cord.

1989 • 23 citations

Development of the amphibian oculomotor complex: Evidences for migration of oculomotor motoneurons across the midline

1991 • 21 citations

SOME ELECTRON MICROSCOPICAL OBSERVATIONS ON THE EPENDYMAL CELLS OF THE CHICK EMBRYO SPINAL CORD.

1964 • 14 citations