Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Automated protein model building combined with iterative structure refinement.

1999 • 2,428 citations

Sparse matrix sampling: a screening method for crystallization of proteins

1991 • 2,050 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Computational Method to Predict Mitochondrially Imported Proteins and their Targeting Sequences

1996 • 1,654 citations

Dali: a network tool for protein structure comparison

1995 • 1,447 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.

1990 • 1,013 citations

DNA Polymerases: Structural Diversity and Common Mechanisms

1999 • 814 citations

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

1992 • 748 citations

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1991 • 511 citations

Structure of CheA, a Signal-Transducing Histidine Kinase

1999 • 471 citations

wARP: Improvement and Extension of Crystallographic Phases by Weighted Averaging of Multiple-Refined Dummy Atomic Models

1997 • 449 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

The design and implementation ofSnBversion 2.0

1999 • 391 citations

Building a Replisome from Interacting Pieces

1999 • 368 citations

DNA Polymerase II

1970 • 330 citations

The Structure of Threonyl-tRNA Synthetase-tRNAThr Complex Enlightens Its Repressor Activity and Reveals an Essential Zinc Ion in the Active Site

1999 • 304 citations

1994 William Allan Award Address. Mitochondrial DNA variation in human evolution, degenerative disease, and aging.

1995 • 270 citations

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.

1999 • 234 citations

The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

1999 • 223 citations

Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps

1995 • 173 citations

Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-dhoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

1989 • 170 citations

Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage 1 1Edited by I. A. Wilson

2000 • 168 citations

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

1996 • 166 citations

The Crystal Structure of an Unusual Processivity Factor, Herpes Simplex Virus UL42, Bound to the C Terminus of Its Cognate Polymerase

2000 • 145 citations

Four helix bundle diversity in globular proteins

1994 • 143 citations

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization

2000 • 141 citations

Purification and identification of subunit structure of the human mitochondrial DNA polymerase.

1992 • 140 citations

A mitochondrial DNA polymerase from embryos of Drosophila melanogaster. Purification, subunit structure, and partial characterization.

1986 • 136 citations

Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus.

1995 • 126 citations

Formation of a Novel Four-Helix Bundle and Molecular Recognition Sites by Dimerization of a Response Regulator Phosphotransferase

1998 • 108 citations

The Accessory Subunit of Xenopus laevis Mitochondrial DNA Polymerase γ Increases Processivity of the Catalytic Subunit of Human DNA Polymerase γ and Is Related to Class II Aminoacyl-tRNA Synthetases

1999 • 108 citations

Mitochondrial DNA polymerases from yeast to man: a new family of polymerases

1997 • 102 citations

Crystal structure of a eukaryote/archaeon-like prolyl-tRNA synthetase and its complex with tRNAPro(CGG)

2000 • 94 citations

The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp

1999 • 87 citations

Efficient Incorporation of Anti-HIV Deoxynucleotides by Recombinant Yeast Mitochondrial DNA Polymerase

1995 • 73 citations

Herpes Simplex Virus Processivity Factor UL42 Imparts Increased DNA-Binding Specificity to the Viral DNA Polymerase and Decreased Dissociation from Primer-Template without Reducing the Elongation Rate

2006 • 53 citations

Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase

2000 • 51 citations

Herpes Simplex Virus Processivity Factor UL42 Imparts Increased DNA-Binding Specificity to the Viral DNA Polymerase and Decreased Dissociation from Primer-Template without Reducing the Elongation Rate

1999 • 50 citations

The gamma subfamily of DNA polymerases: cloning of a developmentally regulated cDNA encoding Xenopus laevis mitochondrial DNA polymerase gamma

1996 • 50 citations

Yeast mitochondrial DNA polymerase is related to the family A DNA polymerases

1990 • 48 citations

Subunit Structure of Mitochondrial DNA Polymerase from Drosophila Embryos

1995 • 39 citations

[1] Shake-and-bake: An algorithm for automatic solution ab initio of crystal structures

1997 • 37 citations

Glycyl‐tRNA synthetase from Thermus thermophilus

1998 • 30 citations