Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity.

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments

1979 • 967 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

A mutant of Saccharomyces cerevisiae defective for nuclear fusion.

1976 • 530 citations

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

1991 • 495 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Compilation and alignment of DNA polymerase sequences

1991 • 339 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Efficient oligonucleotide-directed construction of mutations in expression vectors by the gapped duplex DNA method using alternating selectable markers

1989 • 321 citations

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

1991 • 279 citations

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

1991 • 277 citations

Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis

1989 • 258 citations

The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

1991 • 230 citations

Mitochondrial DNA mutations and neuromuscular disease

1989 • 216 citations

Cloning and Sequencing of the Nuclear Gene MIP1 Encoding the Catalytic Subunit of the Yeast Mitochondrial DNA Polymerase

1989 • 210 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

PIF1: a DNA helicase in yeast mitochondria.

1991 • 198 citations

Spectrophotometric quantitation of silver grains eluted from autoradiograms

1983 • 195 citations

Kinetic basis of spontaneous mutation

1982 • 187 citations

Exonucleolytic proofreading enhances the fidelity of DNA synthesis by chick embryo DNA polymerase-gamma.

1988 • 167 citations

Processive replication is contingent on the exonuclease subunit of DNA polymerase III holoenzyme.

1990 • 128 citations

The 31-kDa polypeptide is an essential subunit of the vacuolar ATPase in Saccharomyces cerevisiae.

1990 • 105 citations

Genome organization of the killer plasmid pGK12 from Kluyveromyces lactis

1988 • 97 citations

Complete DNA Sequence coding for the large ribosomal RNA of yeast mitochondria

1983 • 89 citations

DNA polymerase γ from Xenopus laevis

1989 • 86 citations

Construction of a yeast mutant lacking the mitochondrial nuclease

1988 • 74 citations

MITOCHONDRIAL GENETICS VII. ALLELISM AND MAPPING STUDIES OF RIBOSOMAL MUTANTS RESISTANT TO CHLORAMPHENICOL, ERYTHROMYCIN AND SPIRAMYCIN IN S. CEREVISIAE

1974 • 70 citations

Exonucleolytic proofreading by a mammalian DNA polymerase .gamma.

1989 • 70 citations

DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.

1991 • 69 citations

A nuclear mutant of Saccharomyces cerevisiae deficient in mitochondrial DNA replication and polymerase activity.

1986 • 62 citations

Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals

1991 • 55 citations

Properties of the 3‘ to 5‘ exonuclease associated with porcine liver DNA polymerase gamma. Substrate specificity, product analysis, inhibition, and kinetics of terminal excision.

1991 • 51 citations

Polymerization Activity of an α-Like DNA Polymerase Requires a Conserved 3′-5′ Exonuclease Active Site

1991 • 48 citations

Yeast mitochondrial DNA polymerase is related to the family A DNA polymerases

1990 • 48 citations

Mismatch-specific 3'----5' exonuclease associated with the mitochondrial DNA polymerase from Drosophila embryos.

1989 • 44 citations

Mitochondrial diseases: Gene mapping and gene therapy

1990 • 44 citations

Mitochondrial DNA polymerase from Drosophila melanogaster embryos: kinetics, processivity, and fidelity of DNA polymerization

1988 • 42 citations

MIP1 DNA polymerase of S.cerevisiae: structural similarity with theE.coliDNA polymerase I-type enzymes

1991 • 22 citations