Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

Vitamin D

1979 • 3,814 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study

2001 • 1,927 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,778 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,556 citations

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease

2006 • 1,440 citations

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

2007 • 1,193 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

Vitamin D

2005 • 1,077 citations

1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

2001 • 849 citations

1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter

2007 • 480 citations

Antiproteinuric effect of oral paricalcitol in chronic kidney disease

2005 • 371 citations

Diet-induced Obesity in C57BL/6J Mice Causes Increased Renal Lipid Accumulation and Glomerulosclerosis via a Sterol Regulatory Element-binding Protein-1c-dependent Pathway

2005 • 365 citations

Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population

2009 • 365 citations

Role of Sterol Regulatory Element-binding Protein 1 in Regulation of Renal Lipid Metabolism and Glomerulosclerosis in Diabetes Mellitus

2002 • 327 citations

Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease

2008 • 324 citations

Renoprotective role of the vitamin D receptor in diabetic nephropathy

2007 • 296 citations

The RAAS in the pathogenesis and treatment of diabetic nephropathy

2010 • 296 citations

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

2008 • 285 citations

Paricalcitol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy

2006 • 283 citations

Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVBdb/db Mice With Type 2 Diabetes

2005 • 281 citations

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

2006 • 277 citations

Suppression of renin–angiotensin gene expression in the kidney by paricalcitol

2008 • 262 citations

Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease

2010 • 258 citations

Effect of 1,25(OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats

1998 • 248 citations

Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor–Mediated Sequestration of NF-κB Signaling

2008 • 247 citations

1,25-Dihydroxyvitamin D₃decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat

2004 • 221 citations

Vitamin D Receptor Attenuates Renal Fibrosis by Suppressing the Renin-Angiotensin System

2010 • 220 citations

Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy

2007 • 213 citations

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

2010 • 197 citations

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and a Vitamin D Analog Suppresses the Progression of Renal Insufficiency in Uremic Rats

2007 • 196 citations

Oral Paricalcitol in the Treatment of Patients With CKD and Proteinuria: A Randomized Trial

2009 • 188 citations

Epidemiology of disease risks in relation to vitamin D insufficiency

2006 • 181 citations

1,25-Dihydroxyvitamin D3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells

2007 • 169 citations

The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria

2009 • 163 citations

Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients

2008 • 160 citations

A Vitamin D Analog Ameliorates Glomerular Injury on Rat Glomerulonephritis

2001 • 138 citations

The impact of vitamin D deficiency on diabetes and cardiovascular risk

2010 • 134 citations

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation

2008 • 132 citations

Renoprotective effects of vitamin D analogs

2009 • 129 citations

Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes

2010 • 127 citations

A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes

2010 • 124 citations

Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium

2008 • 120 citations

Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats

2001 • 116 citations

Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease

2005 • 115 citations

Mechanism of Vitamin D Receptor Action

2006 • 108 citations

1,25-Dihydroxyvitamin D₃suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway

2009 • 102 citations

1,25-dihydroxyvitamin D3 inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression

2005 • 102 citations

Oral Calcitriol for the Treatment of Persistent Proteinuria in Immunoglobulin A Nephropathy: An Uncontrolled Trial

2008 • 93 citations

Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT₁ receptor antagonist

2009 • 91 citations

Calorie Restriction Modulates Renal Expression of Sterol Regulatory Element Binding Proteins, Lipid Accumulation, and Age-Related Renal Disease

2005 • 83 citations

22-Oxacalcitriol prevents progressive glomerulosclerosis without adversely affecting calcium and phosphorus metabolism in subtotally nephrectomized rats

2002 • 79 citations

Partial prevention of active Heymann nephritis by 1α, 25 dihydroxyvitamin D3

1993 • 75 citations

Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis

2007 • 68 citations

Potential role of active vitamin D in retarding the progression of chronic kidney disease

2006 • 68 citations

Potential for vitamin D receptor agonists in the treatment of cardiovascular disease

2009 • 67 citations

Effects of increasing doses of 1α-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women

1994 • 64 citations

1α,25‐dihydroxyvitamin D₃ triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo

2009 • 60 citations

Myocardial effects of VDR activators in renal failure

2010 • 56 citations

1,25-Dihydroxyvitamin D<sub>3</sub> Prevents Puromycin Aminonucleoside-Induced Apoptosis of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/Akt-Signaling Pathway

2009 • 53 citations

Treatment with 1, 25-Dihydroxyvitamin D3 Preserves Glomerular Slit Diaphragm-Associated Protein Expression in Experimental Glomerulonephritis

2005 • 47 citations

Association between 25-hydroxyvitamin D deficiency and cardiovascular disease in type 2 diabetic patients with mild kidney dysfunction

2007 • 46 citations

Comparative Review of the Pharmacokinetics of Vitamin D Analogues

2002 • 41 citations

Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney

2008 • 36 citations

Nuclear hormone receptors in diabetic nephropathy

2010 • 34 citations