Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

A Human Homolog of Angiotensin-converting Enzyme

2000 • 1,970 citations

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease

2007 • 1,720 citations

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

2008 • 1,539 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

2007 • 1,193 citations

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

2008 • 1,098 citations

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

2004 • 813 citations

Meta-analysis: Effect of Monotherapy and Combination Therapy with Inhibitors of the Renin–Angiotensin System on Proteinuria in Renal Disease

2008 • 702 citations

The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition

2007 • 695 citations

Glomerular Localization and Expression of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting Enzyme

2006 • 477 citations

Renin-Angiotensin-Aldosterone System and Progression of Renal Disease

2006 • 451 citations

Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

2005 • 424 citations

Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function

2000 • 417 citations

11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

2005 • 360 citations

Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design

2009 • 308 citations

Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney

2008 • 305 citations

A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger Protein

2006 • 304 citations

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

2008 • 289 citations

Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury

2007 • 260 citations

Change in Proteinuria After Adding Aldosterone Blockers to ACE Inhibitors or Angiotensin Receptor Blockers in CKD: A Systematic Review

2008 • 254 citations

Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic Rats

2007 • 252 citations

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

2005 • 247 citations

Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study

2007 • 240 citations

Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7)

2005 • 235 citations

Chymase Is Upregulated in Diabetic Nephropathy

2003 • 223 citations

Elevated Blood Pressure and Heart Rate in Human Renin Receptor Transgenic Rats

2006 • 221 citations

Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Renin-Angiotensin System Status in Hypertensive Patients

2008 • 205 citations

Urinary Angiotensinogen as a Marker of Intrarenal Angiotensin II Activity Associated with Deterioration of Renal Function in Patients with Chronic Kidney Disease

2007 • 191 citations

The Collecting Duct Is the Major Source of Prorenin in Diabetes

2008 • 168 citations

Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

2007 • 167 citations

Renal and Hormonal Responses to Direct Renin Inhibition With Aliskiren in Healthy Humans

2008 • 166 citations

Renal Effects of Aliskiren Compared With and in Combination With Irbesartan in Patients With Type 2 Diabetes, Hypertension, and Albuminuria

2009 • 157 citations

Effect of intrarenal angiotensin II blockade on renal function in conscious dogs.

1977 • 145 citations

Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes

2008 • 135 citations

AT₁receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats

2005 • 128 citations

Complement Activation in Angiotensin II–Induced Organ Damage

2005 • 126 citations

Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus

2003 • 120 citations

Local Renal Aldosterone System and Its Regulation by Salt, Diabetes, and Angiotensin II Type 1 Receptor

2005 • 119 citations

Increased Urinary Angiotensinogen Is Precedent to Increased Urinary Albumin in Patients With Type 1 Diabetes

2009 • 118 citations

Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis

2008 • 98 citations

Young Scholars Award Lecture: Intratubular Angiotensinogen in Hypertension and Kidney Diseases

2006 • 94 citations

Role of the 11β-hydroxysteroid dehydrogenase type 2 in blood pressure regulation

2000 • 87 citations

Chronic Increases in Circulating Prorenin Are not Associated With Renal or Cardiac Pathologies

2009 • 77 citations

Immunolocalization of NAD-dependent 11β-hydroxysteroid dehydrogenase in human kidney and colon

1996 • 72 citations

Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions

2009 • 69 citations

Function of connexins in the renal circulation

2007 • 69 citations

Aliskiren Inhibits Intracellular Angiotensin II Levels Without Affecting (Pro)renin Receptor Signals in Human Podocytes

2010 • 65 citations

Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure

2008 • 61 citations

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

2009 • 43 citations

Angiotensin II regulates 11β-hydroxysteroid dehydrogenase type 2 via AT2 receptors

2003 • 42 citations

The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor?

2009 • 41 citations

New insights into the renoprotective actions of the renin inhibitor aliskiren in experimental renal disease

2010 • 34 citations

Aliskiren/valsartan combination for the treatment of cardiovascular and renal diseases

2009 • 15 citations

Angiotensin administration stimulates renal 11β-hydroxysteroid dehydrogenase activity in healthy men

2004 • 6 citations