Protein tyrosine kinases in nervous system development

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Identification of a transformation-specific antigen induced by an avian sarcoma virus

1977 • 931 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein

1978 • 673 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster

1976 • 395 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

Expression of fasciclin I and II glycoproteins on subsets of axon pathways during neuronal development in the grasshopper

1987 • 366 citations

Sequence analysis and neuronal expression of fasciclin I in grasshopper and drosophila

1988 • 363 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

pp60c-src is developmentally regulated in the neural retina

1984 • 299 citations

Neural Tissues Express High Levels of the Cellular src Gene Product pp60^c-src

1983 • 288 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states.

1980 • 255 citations

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

1991 • 252 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

1986 • 230 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain.

1990 • 228 citations

Fibroblast Growth Factor Receptors from Liver Vary in Three Structural Domains

1991 • 227 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Cell-cell interaction in the drosophila retina: The bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

1988 • 209 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

The nucleotide sequence and the tissue-specific expression of Drosophila c-src

1985 • 201 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes

1992 • 197 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Hormones and growth factors induce the synthesis of glial fibrillary acidic protein in rat brain astrocytes

1985 • 195 citations

c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

1988 • 193 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Neural tissues express high levels of the cellular src gene product pp60c-src.

1983 • 179 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

1990 • 164 citations

Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells

1987 • 163 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

1986 • 151 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

pp60c-src in the developing cerebellum.

1985 • 147 citations

Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes.

1990 • 137 citations

Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product

1991 • 133 citations

Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling.

1981 • 133 citations

The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.

1987 • 133 citations

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

1986 • 131 citations

Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product.

1985 • 129 citations

Structure and developmental expression of the chicken NGF receptor

1990 • 120 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

Characterization of the Neuronal Receptor for Basic Fibroblast Growth Factor and Comparison to Receptors on Mesenchymal Cells

1989 • 113 citations

Glycosylation of the basic fibroblast growth factor receptor. The contribution of carbohydrate to receptor function.

1988 • 112 citations

Induction of Altered c- src Product During Neural Differentiation of Embryonal Carcinoma Cells

1986 • 111 citations

The Drosophila abelson proto-oncogene homolog: Identification of mutant alleles that have pleiotropic effects late in development

1987 • 105 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

pp60c-src kinase is in chick and human embryonic tissues

1984 • 103 citations

The Mechanism of Action of Nerve Growth Factor

1991 • 102 citations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.

1989 • 99 citations

Alterations in pp60^c-src Accompany Differentiation of Neurons from Rat Embryo Striatum

1987 • 90 citations

The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.

1990 • 88 citations

The neurite-promoting effect of fibroblast growth factor on PC12 cells

1983 • 88 citations

Identification of a Novel Neuronal C-SRC Exon Expressed in Human Brain

1990 • 88 citations

Ubiquitous Expression of sevenless : Position-Dependent Specification of Cell Fate

1989 • 79 citations

Immunocytochemical localization of the neuron-specific form of the c- src gene product, pp60c-src(+), in rat brain

1990 • 76 citations

Cellular proteins homologous to the viral yes gene product.

1986 • 74 citations

Differential expression of the cellular src gene during vertebrate development

1984 • 73 citations

Identification of the fibroblast growth factor receptor in human vascular endothelial cells

1988 • 72 citations

Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period

1989 • 69 citations

p60c-src is complexed with a cellular protein in subcellular compartments involved in exocytosis.

1988 • 69 citations

Isolation and oncogenic potential of a novel human src-like gene.

1986 • 69 citations

DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.

1988 • 67 citations

Brain-specific src oncogene mRNA mapped in rat brain by in situ hybridization.

1988 • 66 citations

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

1991 • 60 citations

Differential developmental expression of cellular yes and cellular src proteins in cerebellum.

1988 • 60 citations

Protein tyrosine kinases and phosphatases in the nervous system

1991 • 59 citations

Identification of a novel neuronal C-SRC exon expressed in human brain.

1990 • 57 citations

Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum.

1987 • 56 citations

Differentiation of PC12 cells with v‐src: Comparison with nerve growth factor

1989 • 55 citations

An early developmental phase of pp60c-src expression in the neural ectoderm

1986 • 54 citations

Developmental expression of two forms of pp60c-src in mouse brain.

1988 • 48 citations

A serological assay for the detection of cell surface receptors of nerve growth factor

1978 • 48 citations

The heterogeneity of nerve growth factor receptors.

1979 • 45 citations

pp60^c‐src encoded by the proto‐oncogene c‐src is a product of sensory neurons

1986 • 41 citations

Increased expression of pp60^c‐src protein‐tyrosine kinase during peripheral nerve regeneration

1991 • 39 citations

An altered form of pp60c-src is expressed primarily in the central nervous system.

1987 • 37 citations

Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues

1984 • 36 citations

Localization of pp60c- in growth cone of PC12 cell

1988 • 35 citations

Expression of v-src induces aberrant development and twinning in chimaeric mice

1991 • 35 citations

Neurite extension and protein tyrosine phosphorylation elicited by inducible expression of the v-src oncogene in a PC12 cell line*1

1991 • 30 citations

Expression of the yes proto-oncogene in cerebellar Purkinje cells.

1989 • 30 citations

Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates.

1991 • 26 citations

Roles of Drosophila Proto-oncogene and Growth Factor Homologs During Development of the Fly

1989 • 23 citations

Cell type and developmental regulation of the fyn proto-oncogene in neural retina.

1992 • 21 citations

The founding of The Journal of Comparative Neurology

1991 • 21 citations

Altered expression of pp60^c‐src induced by peripheral nerve injury

1992 • 19 citations

Developmental regulation of protein tyrosine phosphorylation in rat brain

1988 • 18 citations

V max. activation of pp60c-src tyrosine kinase from neuroblastoma neuro-2A

1987 • 15 citations

c-yes protein kinase is associated with a 38 kD protein in cerebellum.

1991 • 9 citations

Expression of pp60c-src in adult and developing rat central nervous system

1989 • 9 citations

Receptor tyrosine kinases mediate cell-cell interactions during Drosophila development

1990 • 5 citations

Deleted Work

1955 • 0 citations