Mechanisms of Corticosteroid Resistance in Rheumatoid Arthritis

Gene regulation by steroid hormones

1989 • 3,466 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Anti-inflammatory actions of steroids: molecular mechanisms

1993 • 740 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

1996 • 670 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

1993 • 457 citations

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1997 • 413 citations

The genomic structure of the human glucocorticoid receptor.

1991 • 397 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor

1994 • 389 citations

Suppression of Macrophage Activation and T-Lymphocyte Function in Hypoprolactinemic Mice

1988 • 387 citations

Inhibition of nuclear hormone receptor activity by calreticulin

1994 • 372 citations

Molecular mechanisms of anti‐inflammatory action of glucocorticoids

1996 • 313 citations

GH3 pituitary adenoma cells can reverse thymic aging in rats.

1986 • 282 citations

Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease.

1982 • 241 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation.

1992 • 219 citations

Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System

1997 • 219 citations

Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

1993 • 211 citations

Inhibition of lymphocyte proliferation by antibodies to prolactin ¹

1989 • 197 citations

Regulation of interleukin 2-driven T-lymphocyte proliferation by prolactin.

1990 • 194 citations

The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role.

1996 • 182 citations

Sex Hormones and Pregnancy in Rheumatoid Arthritis and Systemic Lupus Erythematosus

1999 • 173 citations

Spontaneous Hypercortisolism without Cushing's Syndrome

1976 • 163 citations

The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.

1994 • 158 citations

Requirement of Nuclear Prolactin for Interleukin-2—Stimulated Proliferation of T Lymphocytes

1991 • 156 citations

The Non-Ligand Binding β-Isoform of the Human Glucocorticoid Receptor (hGRβ): Tissue Levels, Mechanism of Action, and Potential Physiologic Role

1996 • 146 citations

Prolactin and Neuroimmunomodulation: In Vitro and in Vivo Observations

1999 • 136 citations

Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry.

1994 • 135 citations

Modulatory effect of prolactin on the resting and mitogen-induced activity of T, B, and NK lymphocytes

1992 • 109 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

1995 • 105 citations

Prolactin Activates Tyrosyl Phosphorylation of Insulin Receptor Substrate 1 and Phosphatidylinositol-3-OH Kinase

1997 • 103 citations

The proline-rich motif (PRM): a novel feature of the cytokine/hematopoietin receptor superfamily.

1993 • 85 citations

Prolactin Receptor Regulates Stat5 Tyrosine Phosphorylation and Nuclear Translocation by Two Separate Pathways

1998 • 74 citations

RECIPROCAL INTERACTIONS BETWEEN THE NEUROENDOCRINE AND IMMUNE SYSTEMS DURING INFLAMMATION

2000 • 74 citations

Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.

1995 • 71 citations

IL-10 inhibits the synthesis of migration inhibitory factor and migration inhibitory factor-mediated macrophage activation.

1993 • 71 citations

Enhanced Yields of Gamma Interferon in Prolactin Treated Human Peripheral Blood Mononuclear Cells

1994 • 65 citations

The effects of hydrocortisone on in vitro lymphocyte proliferation and interleukin‐2 and ‐4 production in corticosteroid sensitive and resistant subjects

1993 • 55 citations

Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry

1994 • 55 citations

Activation of Phosphatidylinositol 3-Kinase by Prolactin in Nb2 Cells

1996 • 46 citations

Neuroendocrine immune responses to inflammation: the concept of the neuroendocrine immune loop

1996 • 46 citations

Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients

1997 • 46 citations

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

1996 • 45 citations

Comparison of Glucocorticoid-Induced Effects in Prolactin-Dependent and Autonomous Rat Nb2 Lymphoma Cells

1993 • 45 citations

MAO Inhibitors, Clorgyline and Lazabemide, Prevent Hydroxyl Radical Generation Caused by Brain Ischemia/Reperf usion in Mice

1995 • 36 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless

1995 • 32 citations

Five Patients with Biochemical and/or Clinical Generalized Glucocorticoid Resistance without Alterations in the Glucocorticoid Receptor Gene

2000 • 30 citations

Why Do We Need New Treatments for Rheumatoid Arthritis?

1998 • 27 citations

Mutually Antagonistic Effects of Corticosterone and Prolactin on Rat Lymphocyte Proliferation

1992 • 25 citations

Cortisol Resistance in Man

1986 • 20 citations

Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor

1995 • 18 citations