Glucocorticoids Inhibit Calcium- and Calcineurin-Dependent Activation of the Human IL-4 Promoter

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation

1997 • 371 citations

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma.

1995 • 355 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Functions of IL-4 and Control of Its Expression

2017 • 337 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Prednisolone Treatment in Asthma Is Associated with Modulation of Bronchoalveolar Lavage Cell Interleukin-4, Interleukin-5, and Interferon-γ Cytokine Gene Expression

1993 • 307 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Functions of IL-4 and Control of Its Expression

1997 • 290 citations

On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

1990 • 279 citations

Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.

1995 • 272 citations

Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa.

1996 • 266 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

1992 • 246 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

1997 • 176 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.

1993 • 167 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells

1999 • 160 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Novel mechanism for inhibition of human T cells by glucocorticoids. Glucocorticoids inhibit signal transduction through IL-2 receptor.

1993 • 151 citations

A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region

1995 • 146 citations

Glucocorticoids suppress the production of interleukin 4 by human lymphocytes

1991 • 140 citations

T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6

1997 • 133 citations

T-Cell Receptor Stimulation Elicits an Early Phase of Activation and a Later Phase of Deactivation of the Transcription Factor NFAT1

1996 • 129 citations

On the mechanism of DNA binding by nuclear hormone receptors: A structural and functional perspective

1993 • 125 citations

Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.

1994 • 110 citations

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

1993 • 103 citations

Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses

1997 • 102 citations

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

1995 • 92 citations

Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities

1987 • 89 citations

Biology and genetics of atopic disease

1996 • 87 citations

Nuclear factor-IL6 activates the human IL-4 promoter in T cells.

1995 • 85 citations

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

1992 • 83 citations

Nuclear Factor of Activated T Cells Is Associated with a Mast Cell Interleukin 4 Transcription Complex

1996 • 78 citations

Redundant expression but selective utilization of nuclear factor of activated T cells family members.

1997 • 70 citations

The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression.

1994 • 64 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 64 citations

Abnormal IL-4 Gene Expression by Atopic Dermatitis T Lymphocytes Is Reflected in Altered Nuclear Protein Interactions with IL-4 Transcriptional Regulatory Element

1996 • 63 citations

The Ca²⁺/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene

1994 • 62 citations

Glucocorticoid Suppresses Autocrine Survival of Mast Cells by Inhibiting IL-4 Production and ICAM-1 Expression

1999 • 57 citations

T Cell Priming Enhances IL-4 Gene Expression by Increasing Nuclear Factor of Activated T Cells

1999 • 50 citations

Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P).

1994 • 45 citations

Regulation of IgE-dependent IL-4 generation by human basophils treated with glucocorticoids.

1997 • 44 citations

Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients

1995 • 32 citations

An activation-responsive element in the murine IL-4 gene is the site of an inducible DNA-protein interaction.

1993 • 29 citations

NF-ATc Isoforms Are Differentially Expressed and Regulated in Murine T and Mast Cells

1999 • 29 citations

Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins

1997 • 29 citations

GLUCOCORTICOIDS REGULATE CALCINEURIN-DEPENDENT TRANS-ACTIVATING PATHWAYS FOR INTERLEUKIN-2 GENE TRANSCRIPTION IN HUMAN T LYMPHOCYTES

1995 • 28 citations

Signal Requirements for Interleukin 4 Promoter Activation in Human T Cells

1996 • 25 citations

GLUCOCORTICOIDS REGULATE CALCINEURIN-DEPENDENT TRANS-ACTIVATING PATHWAYS FOR INTERLEUKIN-2 GENE TRANSCRIPTION IN HUMAN T LYMPHOCYTES

1995 • 24 citations

Purification and Stabilization of Transcriptionally Active Glucocorticoid Receptor

1996 • 24 citations

Inhibition of inflammatory cell recruitment by glucocorticoids: Cytokines as primary targets

1995 • 17 citations

Fos is a Preferential Target of Glucocorticoid Receptor Inhibition of AP-1 Activity In Vitro

1993 • 15 citations