CTL activation is induced by cross-linking of TCR/MHC-peptide-CD8/p56lck adducts in rafts

Functional rafts in cell membranes

1997 • 9,471 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

LAT

1998 • 1,251 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

1999 • 312 citations

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

2000 • 281 citations

Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

1998 • 254 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Rapid Plasma Membrane Anchoring of Newly Synthesized p59 fyn: Selective Requirement for NH2-Terminal Myristoylation and Palmitoylation at Cysteine-3

1997 • 186 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

Localization of LAT in Glycolipid-enriched Microdomains Is Required for T cell Activation

1999 • 166 citations

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

1997 • 160 citations

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

2000 • 143 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction

1999 • 110 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Role of CD8β Domains in CD8 Coreceptor Function

2000 • 105 citations

Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.

1992 • 105 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

The Efficiency of Antigen Recognition by CD8+ CTL Clones Is Determined by the Frequency of Serial TCR Engagement

1998 • 96 citations

CD45 and Src-family kinases: and now for something completely different

1999 • 87 citations

Biochemical Association of CD45 with the T Cell Receptor Complex

1999 • 70 citations

Antigen-Specific Signaling by a Soluble, Dimeric Peptide/Major Histocompatibility Complex Class II/Fc Chimera Leading to T Helper Cell Type 2 Differentiation

1999 • 63 citations

The p56^lck SH2 domain mediates recruitment of CD8/p56^lck to the activated T cell receptor/CD3/ζ complex

1996 • 62 citations

CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity.

1995 • 57 citations

Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative

1995 • 54 citations

Amino-Terminal Palmitate or Polybasic Domain Can Provide Required Second Signal to Myristate for Membrane Binding of P56lck

1995 • 47 citations

The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.

1998 • 44 citations

Selective inhibition of CTL activation by a dipalmitoyl‐phospholipid that prevents the recruitment of signaling molecules to lipid rafts

2001 • 24 citations

Role of CD8 in Aberrant Function of Cytotoxic T Lymphocytes

1997 • 21 citations

Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells.

1997 • 14 citations