CD45 and Src-family kinases: and now for something completely different

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

The when and how of Src regulation

1993 • 543 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Clinical Immunology: Principles and Practice

1996 • 431 citations

Cooperative Inhibition of T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase

1999 • 427 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Clinical Immunology: Principles and Practice

2012 • 396 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.

1996 • 245 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

1996 • 174 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

1997 • 170 citations

CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity.

1990 • 163 citations

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck.

1990 • 142 citations

Inhibitory Tyrosine Protein Kinase p50 Is Associated with Protein-tyrosine Phosphatase PTP-PEST in Hemopoietic and Non-hemopoietic Cells

1997 • 139 citations

Cutting Edge: The CD45 Tyrosine Phosphatase Is an Inhibitor of Lck Activity in Thymocytes

1999 • 135 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases

1994 • 125 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.

1990 • 116 citations

CD45 Modulates Phosphorylation of Both Autophosphorylation and Negative Regulatory Tyrosines of Lyn in B Cells

1996 • 110 citations

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.

1991 • 109 citations

Negative Regulation of CD45 Protein Tyrosine Phosphatase Activity by Ionomycin in T Cells

1991 • 108 citations

A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56^lck and pp³², a possible common substrate

1991 • 104 citations

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

1997 • 102 citations

Correlation of the Phosphorylation States of pp60^c-src with Tyrosine Kinase Activity: The Intramolecular pY530−SH2 Complex Retains Significant Activity If Y419 Is Phosphorylated

1996 • 96 citations

Mutational Analysis of Lck in CD45-Negative T Cells: Dominant Role of Tyrosine 394 Phosphorylation in Kinase Activity

1996 • 94 citations

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

1994 • 92 citations

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.

1992 • 81 citations

The Activated Form of the Lck Tyrosine Protein Kinase in Cells Exposed to Hydrogen Peroxide Is Phosphorylated at Both Tyr-394 and Tyr-505

1997 • 80 citations

CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells.

1991 • 74 citations

Regulation of the p70^zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase

1995 • 65 citations

Demonstration of a Direct Interaction between p56 and the Cytoplasmic Domain of CD45 in Vitro

1996 • 57 citations

Pervanadate simulates the effects of interleukin-2 (IL-2) in human T cells and provides evidence for the activation of two distinct tyrosine kinase pathways by IL-2.

1994 • 56 citations

The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.

1994 • 56 citations

CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line.

1993 • 54 citations

Selective Regulation of Lyn Tyrosine Kinase by CD45 in Immature B Cells

1995 • 52 citations

Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase

1992 • 47 citations

Lymphocyte activation the coming of the protein tyrosine phosphatases

1998 • 37 citations

Detection of a Physical and Functional Interaction between Csk and Lck Which Involves the SH2 Domain of Csk and Is Mediated by Autophosphorylation of Lck on Tyrosine 394

1996 • 36 citations

The Unique Amino-Terminal Domain of p56^lckRegulates Interactions with Tyrosine Protein Phosphatases in T Lymphocytes

1995 • 35 citations

Negative regulation of antigen receptor signaling in lymphocytes

1998 • 34 citations

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

1992 • 34 citations

Identification of the Sites of Interaction between Lymphocyte Phosphatase-associated Phosphoprotein (LPAP) and CD45

1995 • 31 citations

Stimulation of the T-cell antigen receptor-CD3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD45: evidence for two interconnected Lck/Fyn- or zap-70-dependent signaling pathways.

1996 • 30 citations

Induction of hyperphosphorylation and activation of the p56lck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor

1994 • 28 citations

Biochemical analysis of the CD45-p56(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein.

1998 • 19 citations

Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation

1998 • 6 citations