Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

Dendritic cells and the control of immunity

1998 • 14,345 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

1998 • 663 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

1990 • 593 citations

Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

1998 • 569 citations

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

1995 • 519 citations

Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody

1992 • 481 citations

Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.

1998 • 431 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1

1992 • 392 citations

Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

1999 • 384 citations

Effect of Immunization with a Common Recall Antigen on Viral Expression in Patients Infected with Human Immunodeficiency Virus Type 1

1996 • 379 citations

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

1993 • 368 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus.

1991 • 357 citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

1997 • 345 citations

Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine.

1998 • 341 citations

Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus

1998 • 334 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination

1997 • 314 citations

Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection

1997 • 289 citations

Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

1998 • 281 citations

HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers

1999 • 269 citations

Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

1998 • 256 citations

ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.

1995 • 253 citations

Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

1998 • 227 citations

Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus

1998 • 220 citations

Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

1998 • 210 citations

HIV-Specific T-Helper Activity in Seronegative Health Care Workers Exposed to Contaminated Blood

1994 • 201 citations

Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques

1995 • 188 citations

A high frequency of Mamu‐A *01 in the rhesus macaque detected by polymerase chain reaction with sequence‐specific primers and direct sequencing

1997 • 186 citations

Immune responses in HIV-exposed seronegatives: have they repelled the virus?

1995 • 181 citations

Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.

1991 • 171 citations

A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques

1998 • 166 citations

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

1998 • 140 citations

Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239

1997 • 135 citations

Antigen-driven C–C Chemokine-mediated HIV-1 Suppression by CD4+ T Cells from Exposed Uninfected Individuals Expressing the Wild-type CCR-5 Allele

1997 • 122 citations

Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime

1999 • 106 citations

Recombinant modified vaccinia virus Ankara–simian immunodeficiency virusgag polelicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer

1998 • 104 citations

Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques

1997 • 93 citations

A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge

1995 • 87 citations

Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice.

1998 • 84 citations

Antigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes

1998 • 83 citations

Dynamics of Macrophage and T Cell Infection by HIV

1999 • 83 citations

E. coli beta-glucuronidase (GUS) as a marker for recombinant vaccinia viruses.

1995 • 83 citations

Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.

1992 • 76 citations

Gene gun‐based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV

1997 • 72 citations

Immunogenicity of the yeast recombinant p17/p24:Ty virus-like particles (p24-VLP) in healthy volunteers

1995 • 65 citations

A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells

1998 • 52 citations

Protection of monkeys vaccinated with vpr- and/or nef-defective simian immunodeficiency virus strain mac/human immunodeficiency virus type 1 chimeric viruses: a potential candidate live-attenuated human AIDS vaccine.

1997 • 40 citations

A simian immunodeficiency virus envelope V3 cytotoxic T-lymphocyte epitope in rhesus monkeys and its restricting major histocompatibility complex class I molecule Mamu-A*02

1994 • 39 citations

A MHC class I B locus allele-restricted simian immunodeficiency virus envelope CTL epitope in rhesus monkeys.

1995 • 37 citations

Increasedin VitroTetanus-Induced Production of HIV Type 1 Followingin VivoImmunization of HIV Type 1-Infected Individuals with Tetanus Toxoid

1997 • 31 citations

Cytotoxic T-cell response to simian immunodeficiency virus by cynomolgus macaque monkeys immunized with recombinant vaccinia virus

1991 • 30 citations

In vivo resistance to simian immunodeficiency virus superinfection depends on attenuated virus dose.

1998 • 24 citations

Long-term non-progressive human immunodeficiency virus infection: new insights from the simian immunodeficiency virus model.

1997 • 15 citations