The molecular mechanism underlying formation of deletions in Fanconi anemia cells may involve a site-specific recombination.

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment

1991 • 491 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens

1976 • 340 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

Spontane Chromosomenaberrationen bei famili�rer Panmyelopathie

1964 • 311 citations

Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9

1992 • 305 citations

Nucleotide excision repair II: from yeast to mammals

1993 • 304 citations

Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

1987 • 222 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

Site‐specific recombination in the immune system ¹

1991 • 156 citations

V(D)J recombinase-like activity mediates hprt gene deletion in human fetal T-lymphocytes.

1991 • 124 citations

Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus.

1990 • 120 citations

Sequence context effects on 8-methoxypsoralen photobinding to defined DNA fragments

1987 • 117 citations

The mechanism of antigen receptor gene assembly

1989 • 108 citations

MOLECULAR ANALYSIS OF V(D)J RECOMBINATION

1992 • 107 citations

Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination

1993 • 90 citations

V(D)J recombinase-mediated deletion of the hprt gene in T-lymphocytes from adult humans

1992 • 70 citations

V(D)J Recombination in Mammalian Cell Mutants Defective in DNA Double-Strand Break Repair

1993 • 54 citations

Nature of the scid Defect: A Defective VDJ Recombinase System

1989 • 54 citations

Frequencies of HPRT− lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors

1993 • 47 citations

Molecular analyses of in vivo hprt mutations in human t‐lymphocytes: IV. Studies in Newborns

1989 • 47 citations

Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens.

1990 • 41 citations

The genetic defect in DNA repair deficiency syndromes

1993 • 38 citations

The repair of psoralen monoadducts by theEscherichia coliUvrABC endonuclease

1987 • 35 citations

Molecular spectrum of mutations induced at the HPRT locus by a cross-linking agent in human cell lines with different repair capacities

1993 • 31 citations

Increased amount and contour length distribution of small polydisperse circular DNA (spcDNA) in Fanconi anemia

1993 • 30 citations

Mutagenic processing of psoralen monoadducts differ in normal and Fanconi anemia cells

1993 • 23 citations

Excision products of immunoglobulin gene rearrangements

1989 • 17 citations