V(D)J Recombination in Mammalian Cell Mutants Defective in DNA Double-Strand Break Repair

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

The SCID Mouse Mutant: Definition, Characterization, and Potential Uses

1991 • 743 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

VDJ recombination

1992 • 307 citations

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

1991 • 295 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1992 • 189 citations

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

1990 • 178 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

Novel strand exchanges in V(D)J recombination

1988 • 174 citations

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

1983 • 170 citations

Site‐specific recombination in the immune system ¹

1991 • 156 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

GENETICS OF SOMATIC MAMMALIAN CELLS, X. COMPLEMENTATION ANALYSIS OF GLYCINE-REQUIRING MUTANTS

1969 • 135 citations

Cell Cycle Responses of Two X-ray Sensitive Mutants Defective in DNA Repair

1989 • 131 citations

The mechanism of V(D)J recombination: A balance of diversity, specificity, and stability

1992 • 106 citations

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

1992 • 92 citations

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

1991 • 91 citations

The basis for the mechanistic bias for deletional over inversional V(D)J recombination.

1992 • 79 citations

The genetic basis of resistance to ionising radiation damage in cultured mammalian cells

1991 • 72 citations

Extra sequences found at P element excision sites in Drosophila melanogaster

1992 • 52 citations

Germinal and somatic products of Mu1 excision from the Bronze-1 gene of Zea mays

1991 • 32 citations

Genetic analysis of XR-1 mutation in hamster and human hybrids

1989 • 13 citations