Nature of the scid Defect: A Defective VDJ Recombinase System

Somatic generation of antibody diversity

1983 • 3,275 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1981 • 190 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

1988 • 65 citations

Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

1988 • 55 citations

Detection and characterization of functional T cells in mice with severe combined immune deficiency

1988 • 52 citations

Characterization of B lymphocyte lineage progenitor cells from mice with severe combined immune deficiency disease (SCID) made possible by long term culture.

1987 • 44 citations

Transcription of unrearranged antigen receptor genes in scid mice.

1988 • 42 citations

Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level inscid mice

1987 • 41 citations

T-cell receptor and immunoglobulin genes are rearranged together in Abelson virus-transformed pre-B and pre-T cells.

1987 • 41 citations

Early B-cell precursors in scid mice: Normal numbers of cells transformable with abelson murine leukemia virus (A-MuLV)

1988 • 35 citations

Immunoglobulin heavy chain gene diversification in the long‐term bone marrow culture of normal mice and mice with severe combined immunodeficiency

1987 • 28 citations