CD8 memory T cells: cross-reactivity and heterologous immunity

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Epstein-Barr Virus

1986 • 2,255 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

T Cell Anergy

2003 • 1,418 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

T CELL MEMORY

1998 • 863 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever

2003 • 795 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

2003 • 582 citations

DISQUISITIONS ON ORIGINAL ANTIGENIC SIN

1966 • 568 citations

Heterologous immunity provides a potent barrier to transplantation tolerance

2003 • 565 citations

Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis

2003 • 560 citations

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

2000 • 542 citations

Heterologous immunity provides a potent barrier to transplantation tolerance

2003 • 534 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question

2001 • 519 citations

Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection

1998 • 505 citations

No one is naive: the significance of heterologous T-cell immunity

2002 • 465 citations

Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.

1999 • 439 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Pretransplant Frequency of Donor-Specific, IFN-γ-Producing Lymphocytes Is a Manifestation of Immunologic Memory and Correlates with the Risk of Posttransplant Rejection Episodes

1999 • 373 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1998 • 354 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

1994 • 317 citations

Dissecting the Multifactorial Causes of Immunodominance in Class I–Restricted T Cell Responses to Viruses

2000 • 312 citations

The specificity of TCR/pMHC interaction

2002 • 295 citations

Apoptosis Induced In Vitro and In Vivo During Infection by Ebola and Marburg Viruses

2000 • 292 citations

Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression

1995 • 289 citations

Attrition of T Cell Memory

1999 • 278 citations

Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations

1998 • 276 citations

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.

1994 • 275 citations

A computer model of cellular interactions in the immune system

1992 • 271 citations

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

2002 • 259 citations

Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung

2001 • 257 citations

Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans

2000 • 253 citations

Cross-Reactivity between Hepatitis C Virus and Influenza A Virus Determinant-Specific Cytotoxic T Cells

2001 • 233 citations

Varicella in Children With Cancer: Impact of Antiviral Therapy and Prophylaxis

1987 • 222 citations

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

1996 • 219 citations

I<scp>mmunological</scp>M<scp>emory to</scp>V<scp>iral</scp>I<scp>nfections</scp>

2004 • 213 citations

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

2001 • 195 citations

Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy

2002 • 177 citations

A model for simulating cognate recognition and response in the immune system

1992 • 174 citations

PROLONGED SURVIVAL OF MOUSE SKIN ALLOGRAFTS IN RECIPIENTS TREATED WITH DONOR SPLENOCYTES AND ANTIBODY TO CD40 LIGAND1

1997 • 169 citations

Allograft Rejection by Primed/Memory CD8+ T Cells Is CD154 Blockade Resistant: Therapeutic Implications for Sensitized Transplant Recipients

2002 • 168 citations

Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivity

1997 • 166 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response.

1993 • 160 citations

T Cells Primed byLeishmania majorInfection Cross-React with Alloantigens and Alter the Course of Allograft Rejection

2002 • 158 citations

Putative Immunodominant Human Immunodeficiency Virus-Specific CD8⁺T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

2000 • 156 citations

Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients

2000 • 150 citations

T-Cell Allorecognition and Transplant Rejection: A Summary and Update

2003 • 148 citations

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

1988 • 148 citations

Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex.

1975 • 148 citations

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

1995 • 143 citations

Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase

2001 • 141 citations

Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody

2000 • 139 citations

Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus–Induced Immunopathology

2000 • 138 citations

Direct Visualization of Cross-Reactive Effector and Memory Allo-Specific CD8 T Cells Generated in Response to Viral Infections

2003 • 133 citations

Are primary alloresponses truly primary?

1990 • 132 citations

On differences between immunity and immunological memory

2002 • 131 citations

In Vivo Helper Functions of Alloreactive Memory CD4+ T Cells Remain Intact Despite Donor-Specific Transfusion and Anti-CD40 Ligand Therapy

2004 • 130 citations

Specific History of Heterologous Virus Infections Determines Anti-Viral Immunity and Immunopathology in the Lung

2003 • 128 citations

Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.

1981 • 128 citations

Affinity maturation and hypermutation in a simulation of the humoral immune response

1996 • 125 citations

Constrictive (obliterative) bronchiolitis: Diagnosis, etiology, and a critical review of the literature

1998 • 122 citations

Memory T Cells in Transplantation: Generation, Function, and Potential Role in Rejection

2004 • 121 citations

Minimal Bystander Activation of CD8 T Cells during the Virus-induced Polyclonal T Cell Response

1997 • 118 citations

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

2003 • 118 citations

Virus-induced polyclonal cytotoxic T lymphocyte stimulation.

1989 • 116 citations

Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load

2001 • 114 citations

A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

1998 • 110 citations

The organization of mature T-cell pools

1998 • 108 citations

Induction of alloreactive cytotoxic T cells by acute virus infection of mice.

1986 • 107 citations

MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions

1997 • 104 citations

Cutting Edge: Persistent Viral Infection Prevents Tolerance Induction and Escapes Immune Control Following CD28/CD40 Blockade-Based Regimen

2002 • 99 citations

Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection.

1997 • 97 citations

Dynamics of Memory T Cell Proliferation Under Conditions of Heterologous Immunity and Bystander Stimulation

2002 • 93 citations

Molecular mimicry: a mechanism for autoimmune injury ¹

1992 • 89 citations

Squamous Cell Carcinoma in Solid-Organ Transplantation

2002 • 87 citations

Characterization of Virus-Mediated Inhibition of Mixed Chimerism and Allospecific Tolerance

2001 • 87 citations

A Fractal Clonotype Distribution in the CD8+ Memory T Cell Repertoire Could Optimize Potential for Immune Responses

2003 • 86 citations

In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice.

1995 • 81 citations

Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire

1995 • 81 citations

Erythema nodosum

2002 • 80 citations

In remembrance of things past: memory T cells and transplant rejection

2003 • 75 citations

Efficient immune responses in mice lacking N‐region diversity

1995 • 74 citations

Multiple HLA class I‐dependent cytotoxicities constitute the “non‐HLA‐restricted” response in infectious mononucleosis

1987 • 73 citations

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

1998 • 71 citations

Characterization of the T cell-mediated cellular cytotoxicity during acute infectious mononucleosis.

1989 • 69 citations

A systematic approach to vaccine complexity using an automaton model of the cellular and humoral immune system

2000 • 68 citations

Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation

1998 • 64 citations

Comprehensive Early and Lasting Loss of Memory CD8 T Cells and Functional Memory during Acute and Persistent Viral Infections

2004 • 63 citations

Defining Parameters for Successful Immunocytotherapy of Persistent Viral Infection

2000 • 61 citations

Very Diverse CD8 T Cell Clonotypic Responses after Virus Infections

2004 • 61 citations

Characterization of dual-reactive H-2Kb-restricted anti-vesicular stomatitus virus and alloreactive cytotoxic T cells.

1987 • 57 citations

Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection

1997 • 49 citations

Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro

1996 • 46 citations

Attrition of Virus-Specific Memory CD8+ T Cells During Reconstitution of Lymphopenic Environments

2003 • 46 citations

Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous Bacterial Model of Attrition

2002 • 42 citations

Consequences of Cross-Reactive and Bystander CTL Responses during Viral Infections

2000 • 38 citations

Visualizing the Viral Burden: Phenotypic and Functional Alterations of T Cells and APCs during Persistent Infection

2004 • 37 citations

Longitudinal analysis of Mycobacterium tuberculosis 19‐kDa antigen‐specific T cells in patients with pulmonary tuberculosis: association with disease activity and cross‐reactivity to a peptide from HIV_env gp120

2003 • 34 citations

Viral Infection Abrogates CD8+ T-cell Deletion Induced by Costimulation Blockade

2000 • 32 citations

Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection

2003 • 31 citations

Quantitative Analysis of Long-Term Virus-Specific CD8 ⁺ -T-Cell Memory in Mice Challenged with Unrelated Pathogens

2003 • 29 citations

Apoptosis and loss of virus-specific CD8+ T-cell memory

2004 • 27 citations

What Determines Asthma Phenotype?

2000 • 26 citations

Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15

2003 • 24 citations

Alloreactive Cytotoxic T Lymphocytes Lyse Syngeneic Influenza-Infected Tumour Cell Targets

1984 • 12 citations

Cross-reactive recognition of mouse cells expressing the bm3 and bm11 mutations within H-2Kb by H-2Kb-restricted herpes simplex virus-specific cytotoxic T lymphocytes.

1985 • 10 citations

What Causes the Immune System Collapse Seen in AIDS?

1993 • 10 citations

Herpes virus infections, acute rejection, and transplant arteriosclerosis in human cardiac allografts.

1993 • 10 citations

Virus-Induced Immunosuppression

1986 • 5 citations

Cross-reactive recognition of viral and self-peptides by a “public” T cell receptor expressed by cytotoxic T lymphocytes expanded in multiple unrelated individuals

2004 • 4 citations