Apoptosis and loss of virus-specific CD8+ T-cell memory

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis

2003 • 560 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

Attrition of T Cell Memory

1999 • 278 citations

Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection

2003 • 269 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Antiviral response by natural killer cells throughTRAIL gene induction by IFN-α/β

2001 • 262 citations

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

2002 • 259 citations

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

2004 • 235 citations

Differential Sensitivity of Naive and Memory CD8+ T Cells to Apoptosis in Vivo

2002 • 204 citations

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

2001 • 195 citations

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

1999 • 177 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

2002 • 140 citations

The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes.

1977 • 136 citations

Defective generation but normal maintenance of memory T cells in old mice

2002 • 122 citations

Lymphocyte apoptosis during early phase of Listeria infection in mice.

1997 • 121 citations

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

2003 • 118 citations

Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice.

1995 • 116 citations

Dynamic Regulation of T Cell Immunity by CD43

2002 • 112 citations

Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation

2003 • 101 citations

Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells

2002 • 93 citations

Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection

2002 • 90 citations

Virus-Specific CD8 T Cells in Peripheral Tissues Are More Resistant to Apoptosis Than Those in Lymphoid Organs

2003 • 82 citations

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection

1998 • 81 citations

Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice

1998 • 77 citations

The Role of T Cells in Anti-Herpes Simplex Virus Immunity

1977 • 75 citations

Comprehensive Early and Lasting Loss of Memory CD8 T Cells and Functional Memory during Acute and Persistent Viral Infections

2004 • 63 citations

Attrition of Virus-Specific Memory CD8+ T Cells During Reconstitution of Lymphopenic Environments

2003 • 46 citations

Inhibition of TCR-Induced CD8 T Cell Death by IL-12: Regulation of Fas Ligand and Cellular FLIP Expression and Caspase Activation by IL-12

2003 • 44 citations

Mitochondrial Potential and Reactive Oxygen Intermediates in Antigen-Specific CD8+ T Cells During Viral Infection

2003 • 44 citations

Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous Bacterial Model of Attrition

2002 • 42 citations

The Bcl‐2 family pro‐apoptotic molecule, BNIP3 regulates activation‐induced cell death of effector cytotoxic T lymphocytes

2003 • 32 citations

Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection

2003 • 31 citations

Quantitative Analysis of Long-Term Virus-Specific CD8 ⁺ -T-Cell Memory in Mice Challenged with Unrelated Pathogens

2003 • 29 citations

Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15

2003 • 24 citations

A reduction in the number of peripheral CD28+CD8+T cells in the acute phase of influenza

2002 • 23 citations

Bacterial Superantigen Exposure after Resolution of Influenza Virus Infection Perturbs the Virus-Specific Memory CD8⁺-T-Cell Repertoire

2002 • 7 citations