Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

T CELL MEMORY

1998 • 863 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

Activation of human dendritic cells following infection with Mycobacterium tuberculosis.

1997 • 430 citations

Interferon γ Is Required for Activation-induced Death of T Lymphocytes

2002 • 423 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells

2000 • 340 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Induction and regulation of IL-15 expression in murine macrophages.

1996 • 327 citations

IL-15 and IL-2: a matter of life and death for T cells in vivo

2001 • 316 citations

Generation and maintenance of memory CD4+ T Cells

2009 • 303 citations

Attrition of T Cell Memory

1999 • 278 citations

T cell clonal anergy

1997 • 257 citations

On the role of antigen in maintaining cytotoxic T-cell memory.

1996 • 237 citations

Specific assays for cytokine production by T cells

1989 • 228 citations

Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

1996 • 219 citations

T Cell Death and Memory

2001 • 204 citations

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.

1992 • 204 citations

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8⁺memory T cells

2002 • 199 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

2001 • 195 citations

Generation and maintenance of memory T cells

2001 • 179 citations

Intravesical Bacillus Calmette-Guérin therapy for murine bladder tumors: initiation of the response by fibronectin-mediated attachment of Bacillus Calmette-Guérin.

1987 • 159 citations

IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.

1997 • 158 citations

T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.

1998 • 152 citations

Homeostatic regulation of CD8+ T cells by perforin

1999 • 148 citations

IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice.

1996 • 132 citations

Treatment of Superficial Bladder Tumors: Achievements and Needs

2000 • 128 citations

Immunological memory

1997 • 124 citations

Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure

2002 • 120 citations

Enhanced signaling through the IL-2 receptor in CD8⁺T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8⁺T cells rather than promotion of cell death

2002 • 118 citations

Multiple Mechanisms Compensate to Enhance Tumor-Protective CD8+ T Cell Response in the Long-Term Despite Poor CD8+ T Cell Priming Initially: Comparison Between an Acute Versus a Chronic Intracellular Bacterium Expressing a Model Antigen

2002 • 101 citations

Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages

1997 • 98 citations

Tumours can act as adjuvants for humoral immunity

2001 • 85 citations

The emerging role of IL-15 in NK-cell development

2000 • 85 citations

IL-15 Prolongs the Duration of CD8+ T Cell-Mediated Immunity in Mice Infected with a Vaccine Strain ofToxoplasma gondii

1999 • 78 citations

Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.

1995 • 78 citations

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

2000 • 70 citations

Overexpression of IL-15 In Vivo Enhances Protection AgainstMycobacterium bovisBacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses

2001 • 65 citations

Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous Bacterial Model of Attrition

2002 • 42 citations

BCG’s Mechanism of Action – Increasing our Understanding

2000 • 29 citations

Reduction of Bladder Cancer Growth in Mice Treated with Intravesical Bacillus Calmette Guerin and Systemic Interleukin 2

1987 • 27 citations

Progress on Development of the Live BCG Recombinant Vaccine Vehicle for Combined Vaccine Delivery

1995 • 19 citations

Mycobacterium bovisBCG-Infected Mice Are More Susceptible to Staphylococcal Enterotoxin B-Mediated Toxic Shock than Uninfected Mice despite Reduced In Vitro Splenocyte Responses to Superantigens

2002 • 7 citations

Intravescial Bacille Calmette Guerin (BCG) Therapy for Murine Bladder Tumors: Initiation of the Response by Fibronectin-Mediated Attachment of BCG

1987 • 1 citations