The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

The B7–CD28 superfamily

2002 • 1,646 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

2001 • 264 citations

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

2003 • 247 citations

Characterization of Human Inducible Costimulator Ligand Expression and Function

2000 • 237 citations

Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor

2000 • 230 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4⁺T cells

2002 • 221 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

Central Nervous System Expression of IL-10 Inhibits Autoimmune Encephalomyelitis

2001 • 186 citations

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

2000 • 176 citations

CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes

2003 • 164 citations

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

2004 • 160 citations

Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope

1996 • 140 citations

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

2001 • 127 citations

Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-β/interleukin-10 and suppression of experimental autoimmune encephalomyelitis

2003 • 120 citations

Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin

1998 • 101 citations

Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes

2001 • 94 citations

Regulation of T Cell Activation by CD28 and CTLA4

1996 • 84 citations

Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein

1990 • 78 citations

ICOS Ligand Costimulation Is Required for T-Cell Encephalitogenicity

2001 • 78 citations

CTLA-4 and Tolerance: The Biochemical Point of View

2003 • 77 citations

Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis

2002 • 67 citations

PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production

2003 • 50 citations

ICOS Expression by Activated Human Th Cells Is Enhanced by IL-12 and IL-23: Increased ICOS Expression Enhances the Effector Function of Both Th1 and Th2 Cells

2004 • 50 citations

ICOS⁺ Th cells produce distinct cytokines in different mucosal immune responses

2003 • 48 citations

Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis

2002 • 36 citations

Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: synergistic effects of MBP 68-86 and 87-99

1998 • 36 citations

Modulation of experimental autoimmune neuritis in Lewis rats by oral application of myelin antigens

1997 • 28 citations

Combined Nasal Administration of Encephalitogenic Myelin Basic Protein Peptide 68–86 and IL-10 Suppressed Incipient Experimental Allergic Encephalomyelitis in Lewis Rats

2000 • 16 citations