Interleukin‐21 Induces T‐cell Activation and Proinflammatory Cytokine Secretion in Rheumatoid Arthritis

Evolving concepts of rheumatoid arthritis

2003 • 3,428 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?

2001 • 1,237 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 • 955 citations

A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency

1996 • 742 citations

Cutting Edge: IL-21 Is a Switch Factor for the Production of IgG1 and IgG3 by Human B Cells

2004 • 304 citations

Interleukin-21 enhances T-helper cell type I signaling and interferon-γ production in Crohn’s disease

2005 • 287 citations

Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells

2002 • 269 citations

Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: Evidence for a pathogenetic role of B cells

2002 • 255 citations

IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

2002 • 248 citations

Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.

1998 • 234 citations

Ectopic Germinal Center Formation in Rheumatoid Synovitis

2003 • 233 citations

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4–stimulated B cells

2002 • 218 citations

Autoantibodies in rheumatoid arthritis and their clinical significance.

2002 • 196 citations

IL-15 Is Highly Expressed in Inflammatory Bowel Disease and Regulates Local T Cell-Dependent Cytokine Production

2000 • 194 citations

Selective lymphocyte chemokine receptor expression in the rheumatoid joint

2001 • 173 citations

Expression of interleukin‐21 receptor, but not interleukin‐21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis

2004 • 171 citations

Expression of interleukin‐21 receptor in epidermis from patients with systemic sclerosis

2005 • 134 citations

Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis

2004 • 129 citations

Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen

2005 • 129 citations

The Sushi Domain of Soluble IL-15 Receptor α Is Essential for Binding IL-15 and Inhibiting Inflammatory and Allogenic Responses In Vitro and In Vivo

2001 • 96 citations

New therapies for rheumatoid arthritis

2005 • 94 citations

Autoantigens and Immune Pathways in Rheumatoid Arthritis

2002 • 82 citations

Interleukin‐21 is a T‐helper cytokine that regulates humoral immunity and cell‐mediated anti‐tumour responses

2004 • 58 citations

The role of innate cytokines in inflammatory response

2003 • 56 citations

Intestinal Epithelial Antigen Induces Mucosal CD8 T Cell Tolerance, Activation, and Inflammatory Response

2004 • 45 citations

Tumour necrosis factor-alpha (TNF-α) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice

2000 • 41 citations