Exploring the role of cancer stem cells in radioresistance

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

2006 • 6,005 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

2006 • 4,012 citations

Identification and expansion of human colon-cancer-initiating cells

2006 • 3,914 citations

Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

2006 • 2,961 citations

Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

2005 • 2,784 citations

Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data

2000 • 2,411 citations

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

2007 • 2,139 citations

A Perivascular Niche for Brain Tumor Stem Cells

2007 • 2,120 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Hypoxia in cancer: significance and impact on clinical outcome

2007 • 2,062 citations

Cancerous stem cells can arise from pediatric brain tumors

2003 • 1,800 citations

The stem-cell niche as an entity of action

2006 • 1,795 citations

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

2006 • 1,747 citations

Stem Cells and Their Niches

2006 • 1,536 citations

Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

2004 • 1,472 citations

Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor

2006 • 1,305 citations

The Response of CD24 −/low /CD44 + Breast Cancer–Initiating Cells to Radiation

2006 • 1,304 citations

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

2003 • 1,285 citations

A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas

2005 • 1,263 citations

Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State

2005 • 1,076 citations

Hypofractionated Stereotactic Radiotherapy (HypoFXSRT) for Stage I Non-small Cell Lung Cancer: Updated Results of 257 Patients in a Japanese Multi-institutional Study

2007 • 952 citations

Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality

2000 • 925 citations

The role of apoptosis in cancer development and treatment response

2005 • 921 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships

1982 • 843 citations

Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells

2007 • 819 citations

HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth

2006 • 788 citations

CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

2007 • 759 citations

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

2007 • 723 citations

Making a tumour's bed: glioblastoma stem cells and the vascular niche

2007 • 696 citations

WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells

2007 • 595 citations

Hypoxic Radiosensitization: Adored and Ignored

2007 • 593 citations

Radiation oncology: a century of achievements

2004 • 576 citations

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

2007 • 563 citations

In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.

2000 • 498 citations

Cancer Stem Cells in Radiation Resistance

2007 • 488 citations

[Fractionation in radiotherapy].

1972 • 487 citations

The radioresponsiveness of human tumours and the initial slope ofthe cell survival curve

1984 • 472 citations

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

2008 • 464 citations

A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy

2001 • 434 citations

Theragnostic imaging for radiation oncology: dose-painting by numbers

2005 • 398 citations

Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: First clinical trial results

2007 • 372 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Modeling the Initiation and Progression of Human Acute Leukemia in Mice

2007 • 339 citations

A review of ratios for experimental tumors: Implications for clinical studies of altered fractionation

1985 • 334 citations

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

2001 • 300 citations

Advances in Radiation Biology

1975 • 283 citations

Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer

2004 • 283 citations

Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation

1969 • 274 citations

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial

2005 • 268 citations

Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133− cells, and the CD133+ sector is enlarged by hypoxia

2006 • 256 citations

The Relation Between Tumour Lethal Doses and the Radiosensitivity of Tumour Cells

1961 • 246 citations

The 5Rs of Radiobiology

1989 • 240 citations

Successful Therapy Must Eradicate Cancer Stem Cells

2006 • 239 citations

Stereotactic single-dose radiotherapy of stage I non–small-cell lung cancer (NSCLC)

2003 • 234 citations

CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer

2008 • 218 citations

Most C6 Cells Are Cancer Stem Cells: Evidence from Clonal and Population Analyses

2007 • 218 citations

Tumorigenesis of Chemotherapeutic Drug-Resistant Cancer Stem-Like Cells in Brain Glioma

2007 • 214 citations

Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers

2007 • 213 citations

Tumor volume: a basic and specific response predictor in radiotherapy

1998 • 201 citations

Distribution of radiation sensitivities for human tumor cells of specific histological types: Comparison of in vitro to in vivo data

1986 • 193 citations

Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice

2006 • 180 citations

The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix

1997 • 170 citations

Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull

2003 • 167 citations

Wnt/β-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line

2007 • 167 citations

Rodent tumor models in experimental cancer therapy

1988 • 165 citations

The tumor voluem and clonogen number relationship: Tumor control predictions based upon tumor volume estimates derived from computed tomography

1995 • 165 citations

Radiation resistance and stem-like cells in brain tumors

2006 • 158 citations

Influence of oxygen tension on CD133 phenotype in human glioma cell cultures

2007 • 157 citations

Steep Dose–Response Relationship for Stage I Non–Small-Cell Lung Cancer Using Hypofractionated High-Dose Irradiation by Real-Time Tumor-Tracking Radiotherapy

2007 • 154 citations

Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

2007 • 151 citations

Advances in radiation biology

1975 • 149 citations

β1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury

2005 • 148 citations

The value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer: a multicenter analysis

1999 • 148 citations

Spheres Isolated from 9L Gliosarcoma Rat Cell Line Possess Chemoresistant and Aggressive Cancer Stem‐Like Cells

2007 • 142 citations

"Destemming" Cancer Stem Cells

2007 • 142 citations

C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability

2001 • 139 citations

The effect of anaemia on the fraction of hypoxic cells in an experimental tumour

1971 • 119 citations

The proportion of stem cells in murine tumors

1989 • 116 citations

Response of human squamous cell carcinoma xenografts of different sizes to irradiation: relationship of clonogenic cells, cellular radiation sensitivity in vivo, and tumor rescuing units.

1990 • 109 citations

Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlateswith reoxygenation

2001 • 104 citations

Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?

2005 • 103 citations

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariate approach in biomarker studies

2006 • 101 citations

Response of Human Squamous Cell Carcinoma Xenografts of Different Sizes to Irradiation: Relationship of Clonogenic Cells, Cellular Radiation Sensitivity in Vivo, and Tumor Rescuing Units

1990 • 99 citations

Repopulation of γ-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors

1978 • 96 citations

Tumor Cell Radiosensitivity Is a Major Determinant of Tumor Response to Radiation

2006 • 95 citations

Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix

2005 • 94 citations

The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study

2005 • 90 citations

The influence of oxygen on the radiosen-sitivity

1957 • 90 citations

Rodent tumor models in experimental cancer therapy

1987 • 86 citations

Molecular Marker Profiles Predict Locoregional Control of Head and Neck Squamous Cell Carcinoma in a Randomized Trial of Continuous Hyperfractionated Accelerated Radiotherapy

2004 • 86 citations

SURVIVAL CURVES FOR TUMOR CELLS IRRADIATED IN VIVO*

1961 • 85 citations

In vivo radiation sensitivity of glioblastoma multiforme

1995 • 79 citations

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy

2006 • 75 citations

Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC

2004 • 68 citations

Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice

2007 • 65 citations

Tumour stem cells: the biological concept and its application in cancer treatment

1994 • 64 citations

Influence of Tumor Cell and Stroma Sensitivity on Tumor Response to Radiation

2007 • 63 citations

Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse

2003 • 62 citations

Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs

2001 • 62 citations

Radiation response of xenografts of a human squamous cell carcinoma and a glioblastoma multiforme: A progress report

1990 • 62 citations

Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study

2007 • 59 citations

Incorporating biologic measurements (SF2, CFE) into a tumor control probability model increases their prognostic significance: a study in cervical carcinoma treated with radiation therapy

2001 • 57 citations

Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues.

1992 • 55 citations

The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair

2008 • 53 citations

Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation.

2003 • 53 citations

Tumour stem cells

1997 • 51 citations

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: Differential response of cancer stem cells and nontumourigenic cells?

2007 • 51 citations

Multivariate determinants of radiocurability I: Prediction of single fraction tumor control doses

1994 • 50 citations

Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis

2006 • 50 citations

Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas

2004 • 46 citations

Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice

2005 • 41 citations

Influence of Treatment Time on the Response of Rat Rhabdomyosarcoma Rlh to Fractionated Irradiation

1991 • 36 citations

The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times

2005 • 35 citations

Assessing the likelihood of severe side effects in radiotherapy

2006 • 34 citations

Gene profiling in squamous cell carcinoma of the head and neck

2005 • 29 citations

Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

2004 • 23 citations

PAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines of the head and neck

2008 • 23 citations

Multi‐Type Galton‐Watson Process As A Model For Proliferating Human Tumour Cell Populations Derived From Stem Cells: Estimation of Stem Cell Self‐Renewal Probabilities In Human Ovarian Carcinomas

1986 • 17 citations

Effect of the Hypoxic Cell Sensitizer Isometronidazole on Local Control of Two Human Squamous Cell Carcinomas after Fractionated Irradiation

2004 • 16 citations

Biological isoeffect distributions: consideration of the influence of dose per fraction and overall treatment time. A possible tool in future treatment planning.

1991 • 9 citations

1054 The correlation between fractionated TCD50 and different predictive radiobiologic parameters of nine human tumor xenografts into nude mice

1995 • 6 citations

THE USE OF X-RAYS IN CARCINOMA

1905 • 4 citations