Modeling the Initiation and Progression of Human Acute Leukemia in Mice

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

2006 • 1,430 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

2004 • 950 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

2003 • 658 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

Distinct classes of human stem cells that differ in proliferative and self-renewal potential

2001 • 334 citations

Fates of human B-cell precursors

2000 • 256 citations

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

1994 • 212 citations

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

2003 • 205 citations

Use of human tissue to assess the oncogenic activity of melanoma-associated mutations

2005 • 200 citations

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis

2004 • 164 citations

A genetically tractable model of human glioma formation.

2001 • 137 citations

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

2006 • 132 citations

Childhood Acute Lymphoblastic Leukemia With the MLL-ENL Fusion and t(11;19)(q23;p13.3) Translocation

1999 • 111 citations

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology

2006 • 101 citations

The Incidence Peaks of the Childhood Acute Leukemias Reflect Specific Cytogenetic Aberrations

2006 • 79 citations

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis

2005 • 76 citations

The Oncoprotein MLL–ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell

2003 • 61 citations

Age-related changes of lymphocyte subsets in normal bone marrow biopsies

1998 • 57 citations

Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement.

1995 • 49 citations

CongenitalMLL-positive B-cell acute lymphoblastic leukemia (B-ALL) switched lineage at relapse to acute myelocytic leukemia (AML) with persistent t(4;11) and t(1;6) translocations and JH gene rearrangement

2005 • 33 citations

Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.

2006 • 19 citations