Assessing the likelihood of severe side effects in radiotherapy

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

2003 • 1,594 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

2003 • 1,157 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Recombinational DNA double-strand breaks in mice precede synapsis

2001 • 853 citations

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

2004 • 819 citations

Quantitative Detection of¹²⁵IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

2002 • 598 citations

DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

2001 • 529 citations

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

2002 • 529 citations

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 • 496 citations

Ataxia–telangiectasia, an evolving phenotype

2004 • 412 citations

In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

2005 • 398 citations

5 DNA Breakage and Repair

1998 • 363 citations

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity

2004 • 343 citations

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

2000 • 315 citations

Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks.

2003 • 291 citations

Initial Steps of Ferulic Acid Polymerization by Lignin Peroxidase

2001 • 199 citations

Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.

1995 • 193 citations

Evidence for individual differences in the radiosensitivity of human skin

1992 • 193 citations

Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.

2001 • 150 citations

Cancer risk in heterozygotes for ataxia-telangiectasia

2001 • 134 citations

Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer

2000 • 131 citations

The ESTRO Regaud lecture Inherent radio sensitivity of tumor and normal tissue cells as a predictor of human tumor response

1990 • 129 citations

Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity

2001 • 125 citations

Increased cancer risk of heterozygotes with NBS1 germline mutations in poland

2004 • 125 citations

Quantification of late complications after radiation therapy

2001 • 124 citations

Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer

2003 • 115 citations

The Comet Assay: An Overview of Techniques

2003 • 110 citations

Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations

2002 • 109 citations

Describing patients' normal tissue reactions: Concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity

1998 • 108 citations

Harmonising the response to DSBs: a new string in the ATM bow

2005 • 103 citations

Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: Defective rejoining of radioinduced dna strand breaks in lymphocytes of breast cancer patients

1999 • 97 citations

Artemis links ATM to Double Strand Break Rejoining

2005 • 94 citations

Four radiation hypersensitivity cases and their implications for clinical radiotherapy

2000 • 68 citations

Radiation sensitivity of lymphocytes from healthy individuals and cancer patients as measured by the comet assay

2001 • 58 citations

Phosphorylated Histone H2AX in Spheroids, Tumors, and Tissues of Mice Exposed to Etoposide and 3-Amino-1,2,4-Benzotriazine-1,3-Dioxide

2004 • 53 citations

Chromosomal Radiosensitivity in Two Cell Lineages Derived from Clinically Radiosensitive Cancer Patients

2005 • 40 citations

Radiation-Induced Comet-Formation in Human Skin Fibroblasts from Radiotherapy Patients with Different Normal Tissue Reactions

1999 • 36 citations

Theory and practice of predictive assays in radiation therapy

1997 • 23 citations

Clinical and Cellular Radiosensitivity in Inherited Human Syndromes

2004 • 19 citations