Reduced Survival of Rectal Cancer Patients With Increased Tumor Epidermal Growth Factor Receptor Levels

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer

2001 • 4,006 citations

Epidermal Growth Factor

1979 • 2,964 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

2001 • 988 citations

Preoperative Radiotherapy for Resectable Rectal Cancer

2000 • 760 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor.

2001 • 642 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

1985 • 611 citations

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

2000 • 549 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER

1985 • 496 citations

Expression of epidermal growth factor receptor in human gastric and colonic carcinomas.

1988 • 365 citations

Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.

1983 • 327 citations

Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy.

1997 • 314 citations

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1990 • 246 citations

Angiocentric Lymphoma of the Head and Neck: Patterns of Systemic Failure After Radiation Treatment

2000 • 241 citations

Production of transforming growth factors by human colon cancer lines.

1986 • 227 citations

Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification

1994 • 205 citations

PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.

1997 • 205 citations

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

2000 • 200 citations

Growth factor production by human colon carcinoma cell lines.

1989 • 186 citations

Epidermal growth factor-receptor-protein kinase interactions.

1981 • 171 citations

Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer

1991 • 159 citations

Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis

1995 • 156 citations

A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial

1998 • 152 citations

Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2

1998 • 136 citations

Expression of transforming growth factor alpha messenger rna in the normal and neoplastic gastro‐intestinal tract

1989 • 132 citations

Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

1991 • 117 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND ESTROGEN-RECEPTORS IN HUMAN-BREAST CANCER

1985 • 114 citations

Epidermal Growth Factor Receptor as a Genetic Therapy Target for Carcinoma Cell Radiosensitization

2001 • 96 citations

Mechanism of Phosphorylation of the Epidermal Growth Factor Receptor at Threonine 669

1989 • 93 citations

Epidermal growth factor receptor expression in colorectal cancer

1990 • 83 citations

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

1998 • 80 citations

Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells

2002 • 77 citations

Expression of epidermal growth factor receptor in normal colorectal mucosa, adenoma, and carcinoma

1990 • 75 citations

Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes

1998 • 71 citations

New therapeutic agents targeting the epidermal growth factor receptor.

2000 • 63 citations

Transactivation of the Epidermal Growth Factor Receptor Is Involved in 12-O-Tetradecanoylphorbol-13-acetate-induced Signal Transduction

2001 • 61 citations

Enhanced tumorigenesis of NR6 cells which express non-down-regulating epidermal growth factor receptors.

1991 • 53 citations

Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro

1999 • 48 citations

Impact of epidermal growth factor (EGF) radioreceptor analysis on long-term survival of gastric cancer patients.

2002 • 46 citations

Increased epidermal growth factor receptors in gastric carcinomas

1990 • 46 citations

Epidermal growth factor receptor levels are lower in carcinomatous than in normal colorectal tissue

1992 • 41 citations

Protein kinase C activity in human colonic adenoma and colorectal carcinoma

1992 • 39 citations

Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

1997 • 39 citations

Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia.

1991 • 38 citations

Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF‐α/EGF receptor

1993 • 33 citations

Epidermal growth factor, transforming growth factor-?, and epidermal growth factor receptor content in normal and carcinomatous gastric and colonic tissue

1993 • 29 citations

Epidermal growth factor receptors and epidermal growth factor-like activity in colorectal mucosa, adenomas and carcinomas

1989 • 23 citations

Increased transforming growth factor-? levels in human colon carcinoma cell lines over-expressing protein kinase C

1999 • 16 citations

Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma

1992 • 13 citations

Ras Regulation of urokinase-type plasminogen activator

2001 • 8 citations