Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro

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Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

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1994 • 664 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

1993 • 539 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

1995 • 391 citations

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1995 • 317 citations

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

1994 • 287 citations

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1992 • 257 citations

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1989 • 246 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins

1993 • 200 citations

Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

1990 • 149 citations

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1987 • 136 citations

Mechanism of antitumor activity in mice for anti-epidermal growth factor receptor monoclonal antibodies with different isotypes.

1986 • 106 citations

The occurrence of epidermal growth factor receptors and the characterization of EGF-like factors in human ovarian, endometrial, cervical and breast cancer

1989 • 83 citations

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

1998 • 80 citations

Increased Intestinal Bak Expression Results in Apoptosis

1996 • 74 citations

Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling

1996 • 72 citations

Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas

1995 • 66 citations

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1992 • 63 citations

Differential regulation of transforming growth factor alpha autoinduction in a nontransformed and transformed epithelial cell.

1992 • 48 citations

Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.

1991 • 39 citations

Apoptosis in human colorectal tumours: ultrastructure and quantitative studies on tissue localization and association with bak expression

1998 • 33 citations

The degree of inhibition of protein tyrosine kinase activity by tyrphostin 23 and 25 is related to their instability.

1994 • 32 citations

Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice.

1991 • 24 citations

Binding of epidermal growth factor and insulin‐like growth‐factor I in renal carcinoma and adjacent normal kidney tissue

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A Tyrphostin-Derived Inhibitor of Protein Tyrosine Kinases: Isolation and Characterization

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Tyrosine phosphorylation of a Mr 63,000 protein induced by an endogenous mitogen in human colon carcinoma cells, but not in normal colonocytes.

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1988 • 2 citations