Mechanism of Phosphorylation of the Epidermal Growth Factor Receptor at Threonine 669

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

1987 • 357 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

The epidermal growth factor receptor as a multifunctional allosteric protein

1988 • 286 citations

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

1985 • 284 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Multisite phosphorylation of glycogen synthase

1984 • 208 citations

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

1985 • 179 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.

1988 • 112 citations

Further purification of epidermal growth factor by high-performance liquid chromatography

1982 • 103 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.

1985 • 98 citations

Effects of Epidermal Growth Factor and 12-O-Tetradecanoylphorbol-13-Acetate on Metabolism of the Epidermal Growth Factor Receptor in Normal Human Fibroblasts

1984 • 94 citations

Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts.

1987 • 84 citations

Stimulation of protein phosphatase activity by insulin and growth factors in 3T3 cells.

1988 • 83 citations

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.

1988 • 83 citations

Phosphorylation of nerve growth factor receptor proteins in sympathetic neurons and PC12 cells. In vitro phosphorylation by the cAMP-independent protein kinase FA/GSK-3.

1986 • 78 citations

Advances in the analysis of amino acid phenylthiohydantoins by high performance liquid chromatography

1976 • 68 citations

Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.

1987 • 66 citations

Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue.

1988 • 45 citations

Activation of a cytosolic serine protein kinase by epidermal growth factor.

1988 • 43 citations

Phosphorylation of sites 3 and 2 in rabbit skeletal muscle glycogen synthase by a multifunctional protein kinase (ATP-citrate lyase kinase).

1985 • 32 citations

Cyclic nucleotide-independent protein kinase from rat liver. Purification and characterization of a multifunctional protein kinase.

1985 • 30 citations