Protein kinase C activity in human colonic adenoma and colorectal carcinoma

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

ras GENES

1987 • 3,818 citations

The evolution of cancer of the colon and rectum

1975 • 2,120 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer

1987 • 311 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue.

1989 • 211 citations

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids.

1987 • 199 citations

Tritiated thymidine (phi p, phi h) labeling distribution as a marker for hereditary predisposition to colon cancer.

1983 • 191 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

[24] Assay and purification of protein kinase C

1986 • 159 citations

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

1981 • 142 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.

1987 • 119 citations

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

1988 • 94 citations

Partial down-regulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene.

1988 • 63 citations

Differential response of premalignant epithelial cell classes to phorbol ester tumor promoters and to deoxycholic acid.

1981 • 63 citations

1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon.

1990 • 60 citations

Phorbol esters induce both intracellular translocation and down-regulation of protein kinase C in MCF-7 cells

1986 • 56 citations

Studies on Protein Kinase C and Colon Carcinogenesis

1987 • 43 citations

Subcellular distribution of protein kinase C in rat colonic epithelial cells with different proliferative activities.

1987 • 39 citations

Comparative studies on phosphorylation of synthetic peptide analogue of ribosomal protein S6 and 40‐S ribosomal subunits between Ca^{2 +}/phospholipid‐dependent protein kinase and its protease‐activated form

1987 • 20 citations

Altered protein tyrosine kinase levels in human colon carcinoma

1991 • 12 citations

Ionic Strength-Dependent Proteolytic Activation of Protein Kinase C by Trypsin-Like Protease1

1988 • 8 citations