Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Cancer statistics, 1997

1997 • 2,045 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation

1992 • 265 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Overexpression of Protein Kinase C in HT29 Colon Cancer Cells Causes Growth Inhibition and Tumor Suppression

1990 • 179 citations

Protein Kinase C Isozyme-mediated Cell Cycle Arrest Involves Induction of p21 and p27 and Hypophosphorylation of the Retinoblastoma Protein in Intestinal Epithelial Cells

1997 • 143 citations

βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle

1996 • 143 citations

Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ.

1994 • 133 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

1991 • 117 citations

Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.

1990 • 112 citations

Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation.

1992 • 109 citations

Predominant expression of nPKC eta, a Ca(2+)-independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation.

1993 • 108 citations

Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation

1992 • 107 citations

Two Closely Related Isoforms of Protein Kinase C Produce Reciprocal Effects on the Growth of Rat Fibroblasts

1995 • 101 citations

Rapid microassay for protein kinase C translocation in Swiss 3T3 cells

1986 • 100 citations

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

1996 • 99 citations

PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

1992 • 94 citations

Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta.

1995 • 90 citations

Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon

1994 • 80 citations

Activation of α-Protein Kinase C Leads to Association with Detergent-Insoluble Components of GH₄C₁Cells

1990 • 79 citations

Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells.

1998 • 74 citations

The Protein Kinase C Isoforms Leading to MAP-Kinase Activation in CHO Cells

1995 • 61 citations

1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon.

1990 • 60 citations

Increased Expression of Protein Kinase Cβ Activates ERK3

1996 • 59 citations

Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.

1992 • 59 citations

Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control.

1991 • 58 citations

Protein kinase C α modulates growth and differentiation in Caco-2 cells

1998 • 56 citations

Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta.

1994 • 53 citations

Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C β and η mRNAs in the tumors

1994 • 45 citations

Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells.

1996 • 44 citations

Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control

1996 • 43 citations

Cell proliferation in serial biopsies through human malignant brain tumours: Measurement using Ki67 antibody labelling

1991 • 42 citations

Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors

1993 • 40 citations

Protein kinase C activity in human colonic adenoma and colorectal carcinoma

1992 • 39 citations

Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes.

1994 • 39 citations

Overexpression of protein kinase C β1 in the SW480 colon cancer cell line growth suppression

1995 • 38 citations

Localization of protein kinase C isozymes in rat colon.

1995 • 35 citations

Differential Expression of Protein Kinase C Isoforms in Human Colorectal Cancers

1995 • 34 citations

Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors

1991 • 32 citations

Differential Effects of Overexpression of PKCα and PKCδ/ϵ on Cellular E2F Activity in Late G1 Phase

1996 • 29 citations

Differential distribution of protein kinases along the crypt-to-lumen regions of rat colonic epithelium.

1988 • 14 citations

Nonmutagenic Mechanisms in Carcinogenesis: Role of Protein Kinase C in Signal Transduction and Growth Control

1991 • 13 citations

Growth-related enzyme activities in crypt compartments during rat colon carcinogenesis.

1990 • 12 citations