Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Significance of CD44 gene products for cancer diagnosis and disease evaluation

1992 • 470 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Amplification and expression of the human cyclin D gene in esophageal cancer.

1992 • 411 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

1994 • 345 citations

Frequent amplification of the c-met gene in scirrhous type stomach cancer

1992 • 335 citations

Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

1994 • 322 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Expression of CD44R1 adhesion molecule in colon carcinomas and metastases

1993 • 284 citations

Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers.

1994 • 246 citations

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

1992 • 229 citations

Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers.

1992 • 215 citations

Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations.

1991 • 196 citations

An allelotype of squamous carcinoma of the head and neck using microsatellite markers.

1994 • 195 citations

Growth factors and oncogenes in human gastrointestinal carcinomas

1990 • 185 citations

High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.

1989 • 162 citations

Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

1990 • 162 citations

Amplification of the EGF receptor and c‐myc genes in human esophageal cancers

1988 • 147 citations

Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas.

1994 • 138 citations

Reduced Expression of nm23 Is Associated with Metastasis of Human Gastric Carcinomas

1993 • 131 citations

Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors.

1994 • 117 citations

How Cells Cycle Toward Cancer

1994 • 117 citations

Aberrant expression of c‐met mRNA in human gastric carcinomas

1993 • 107 citations

Interleukin 1 alpha acts as an autocrine growth stimulator for human gastric carcinoma cells.

1993 • 85 citations

Cancer, Catenins, and Cuticle Pattern: a Complex Connection

1993 • 84 citations

Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas

1993 • 77 citations

Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas

1994 • 75 citations

Expression of cripto, a Novel Gene of the Epidermal Growth Factor Family, in Human Gastrointestinal Carcinomas

1991 • 63 citations

Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and postreceptor signaling.

1992 • 61 citations

Loss of Heterozygosity at the bcl‐2 Gene Locus and Expression of bcl‐2 in Human Gastric and Colorectal Carcinomas

1994 • 60 citations

Expression of CD44 abnormal transcripts in human gastric carcinomas

1994 • 53 citations

Reduced Levels of Transforming Growth Factor‐beta Type I Receptor in Human Gastric Carcinomas

1992 • 47 citations

Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinomas of the esophagus.

1994 • 35 citations

Expression of cripto in human gastric carcinomas : An association with tumor stage and prognosis

1994 • 20 citations

Growth Factors in Gastric Cancer

1993 • 19 citations

Oncogenes and Tumor Suppressor Genes

1993 • 18 citations

COAMPLIFICATION OF CYCLIN-D, HST-1 AND INT-2 GENES IS A GOOD BIOLOGICAL MARKER OF HIGH MALIGNANCY FOR HUMAN ESOPHAGEAL CARCINOMAS

1994 • 10 citations

Abnormal expression of growth factors and their receptors in stomach cancer

1994 • 8 citations