Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

Investigative Ophthalmology and Visual Science

2010 • 3,019 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells

2004 • 908 citations

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

2006 • 639 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells

2004 • 498 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

1997 • 410 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

2003 • 353 citations

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

2007 • 312 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

2010 • 249 citations

Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression

2004 • 202 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR

1999 • 191 citations

Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand

1999 • 188 citations

GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily

2005 • 173 citations

Inverse correlation between CD4⁺ regulatory T‐cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus

2006 • 172 citations

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity

2006 • 172 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

Cutting Edge: Ligation of the Glucocorticoid-Induced TNF Receptor Enhances Autoreactive CD4+ T Cell Activation and Experimental Autoimmune Encephalomyelitis

2004 • 164 citations

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

2010 • 159 citations

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)

2006 • 157 citations

GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo

2009 • 118 citations

Cloning and characterization of GITR ligand

2003 • 108 citations

Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors

2007 • 106 citations

GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

2004 • 103 citations

Role of glucocorticoid‐induced TNF receptor family gene (GITR) in collagen‐induced arthritis

2005 • 98 citations

Cancer immunoediting by GITR (glucocorticoid‐induced TNF‐related protein) ligand in humans: NK cell/tumor cell interactions

2007 • 97 citations

Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8+ T Cells

2007 • 95 citations

Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes

2006 • 92 citations

Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

2008 • 85 citations

Glucocorticoid-Induced TNF Receptor Functions as a Costimulatory Receptor That Promotes Survival in Early Phases of T Cell Activation

2005 • 79 citations

Glucocorticoid-Induced Tumor Necrosis Factor Receptor–Related Protein Ligand Subverts Immunosurveillance of Acute Myeloid Leukemia in Humans

2009 • 74 citations

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

2008 • 72 citations

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

2008 • 71 citations

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

2007 • 69 citations

In Vivo Kinetics of GITR and GITR Ligand Expression and Their Functional Significance in Regulating Viral Immunopathology

2005 • 69 citations

Glucocorticoid‐induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques

2006 • 68 citations

Glucocorticoid‐induced TNFR family‐related protein (GITR) activation exacerbates murine asthma and collagen‐induced arthritis

2005 • 66 citations

GITR-GITRL System, A Novel Player in Shock and Inflammation

2007 • 65 citations

GITR Ligation Blocks Allograft Protection by Induced CD25+CD4+ Regulatory T Cells without Enhancing Effector T-Cell Function

2007 • 65 citations

Bypassing tumor-associated immune suppression with recombinant adenovirus constructs expressing membrane bound or secreted GITR-L

2004 • 65 citations

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

2007 • 65 citations

Proinflammatory Role of Glucocorticoid-Induced TNF Receptor-Related Gene in Acute Lung Inflammation

2006 • 64 citations

Tumor Necrosis Factor Receptor (TNFR)-associated Factor 5 Is a Critical Intermediate of Costimulatory Signaling Pathways Triggered by Glucocorticoid-induced TNFR in T Cells

2006 • 60 citations

Glucocorticoid-Induced TNF Receptor, a Costimulatory Receptor on Naive and Activated T Cells, Uses TNF Receptor-Associated Factor 2 in a Novel Fashion as an Inhibitor of NF-κB Activation

2005 • 59 citations

Reverse signaling initiated from GITRL induces NF-κB activation through ERK in the inflammatory activation of macrophages

2007 • 58 citations

Expression of Glucocorticoid Induced TNF Receptor Family Related Protein (GITR) on peripheral T cells from normal human donors and patients with non-infectious uveitis

2003 • 54 citations

TRAF4 functions as an intermediate of GITR-induced NF-?B activation

2004 • 54 citations

Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage

2002 • 53 citations

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

2008 • 50 citations

Structural basis for ligand-mediated mouse GITR activation

2008 • 50 citations

GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells

2008 • 48 citations

Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states

2008 • 48 citations

CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis

2008 • 47 citations

In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules

2008 • 45 citations

Soluble glucocorticoid‐induced tumor necrosis factor receptor (sGITR) increased MMP‐9 activity in murine macrophage

2003 • 44 citations

Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritis

2007 • 41 citations

The Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Gene Modulates the Response toCandida albicansInfection

2005 • 41 citations

Genetic and pharmacological inhibition of GITR‐GITRL interaction reduces chronic lung injury induced by bleomycin instillation

2006 • 40 citations

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

2008 • 40 citations

Key Role of the GITR/GITRLigand Pathway in the Development of Murine Autoimmune Diabetes: A Potential Therapeutic Target

2009 • 39 citations

Enhancement of T‐cell‐mediated anti‐tumour immunity via the ectopically expressed glucocorticoid‐induced tumour necrosis factor receptor‐related receptor ligand (GITRL) on tumours

2008 • 39 citations

Glucocorticoid‐induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen‐specific CD8⁺ T cells with tumor regression

2009 • 38 citations

In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

2005 • 37 citations

Glucocorticoid-induced Tumor Necrosis Factor Receptor Is a p21 Transcriptional Target Conferring Resistance of Keratinocytes to UV Light-induced Apoptosis

2005 • 36 citations

Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.

2009 • 35 citations

Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines

2006 • 35 citations

Conversion of Alloantigen-Specific CD8+ T Cell Anergy to CD8+ T Cell Priming through In Vivo Ligation of Glucocorticoid-Induced TNF Receptor

2006 • 33 citations

RECOMBINANT GLUCOCORTICOID INDUCED TUMOUR NECROSIS FACTOR RECEPTOR (rGITR) INDUCED COX-2 ACTIVITY IN MURINE MACROPHAGE Raw 264.7 CELLS

2002 • 31 citations

Constitutive and Cytokine-Induced GITR Ligand Expression on Human Retinal Pigment Epithelium and Photoreceptors

2004 • 31 citations

Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity

2008 • 26 citations

Stimulation of glucocorticoid‐induced tumor necrosis factor receptor family‐related protein ligand (GITRL) induces inflammatory activation of microglia in culture

2010 • 23 citations

The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages

2004 • 21 citations

Co‐inhibitory roles for glucocorticoid‐induced TNF receptor in CD1d‐dependent natural killer T cells

2008 • 20 citations

Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4+ T Cell Responses Enhances Antiparasitic Immunity

2010 • 20 citations

Glucocorticoid‐Induced Tumor Necrosis Factor Receptor Family–Related Protein Triggering Enhances HIV‐Specific CD4⁺T Cell Cytokine Secretion and Protects HIV‐Specific CD4⁺T Cells from Apoptosis

2007 • 19 citations

The GITRL–GITR system alters TLR-4 expression on DC during fungal infection

2009 • 16 citations

Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor

2006 • 15 citations

Immune Rejection of Mouse Tumors Expressing Mutated Self

2009 • 15 citations

Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) and its Ligand (GITRL) in Atopic Dermatitis

2006 • 13 citations

Flow Cytometric Analysis of Expression of Transforming Growth Factor-β and Glucocorticoid-Induced Tumor Necrosis Factor Receptor on CD4+ CD25+ T Cells of Patients with Inflammatory Bowel Disease

2006 • 10 citations

Coating of Tumor Cells by Platelets Confers Expression of Immunoregulatory Molecules Which Impair NK Cell Anti-Tumor Reactivity.

2009 • 4 citations

Prospective Study of Oral Valganciclovir for Pre-Emptive Therapy of Cytomegalovirus After Allogeneic Stem Cell Transplantation.

2009 • 2 citations