Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Diagnosis and Classification of Diabetes Mellitus

2007 • 1,044 citations

Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways

2008 • 951 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

2008 • 499 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

2008 • 354 citations

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2009 • 250 citations

No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes

2007 • 242 citations

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

2008 • 194 citations

IL-27 inhibits the development of regulatory T cells via STAT3

2007 • 180 citations

CD69+CD4+CD25− T Cells, a New Subset of Regulatory T Cells, Suppress T Cell Proliferation through Membrane-Bound TGF-β1

2009 • 180 citations

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

2008 • 165 citations

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

2009 • 150 citations

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

2008 • 116 citations

All-transRetinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

2008 • 112 citations

T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects

2008 • 107 citations

Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells

2007 • 107 citations

A Sudden Decline in Active Membrane-Bound TGF-β Impairs Both T Regulatory Cell Function and Protection against Autoimmune Diabetes

2004 • 104 citations

Regulation of the foxp3 Gene by the Th1 Cytokines: The Role of IL-27-Induced STAT1

2009 • 79 citations

Human Cord Blood Stem Cell-Modulated Regulatory T Lymphocytes Reverse the Autoimmune-Caused Type 1 Diabetes in Nonobese Diabetic (NOD) Mice

2009 • 78 citations

Upregulating CD4+CD25+FOXP3+ Regulatory T Cells in Pancreatic Lymph Nodes in Diabetic NOD Mice by Adjuvant Immunotherapy

2009 • 61 citations

Phenotypic and genetic analyses of T‐cell‐mediated immunoregulation in patients with Type 1 diabetes

2006 • 53 citations

ICOS Mediates the Development of Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice

2008 • 49 citations

Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro

2006 • 47 citations

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation

2008 • 46 citations

The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients

2008 • 36 citations

Validated protocol for FoxP3 reveals increased expression in type 1 diabetes patients

2008 • 36 citations

Association between suppressors of cytokine signalling, T‐helper type 1/T‐helper type 2 balance and allergic sensitization in children

2007 • 24 citations

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2009 • 22 citations

Diverse FOXP3 Expression in Children with Type 1 Diabetes and Celiac Disease

2008 • 21 citations

Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T‐cells from children with type 1 diabetes

2008 • 15 citations