Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

NK CELL RECOGNITION

2004 • 2,685 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

Interferons, immunity and cancer immunoediting

2006 • 1,497 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

2002 • 624 citations

Unravelling natural killer cell function: triggering and inhibitory human NK receptors

2003 • 602 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Prospects for the use of NK cells in immunotherapy of human cancer

2007 • 525 citations

Human natural killer cell development and biology

2005 • 487 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

1997 • 410 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 297 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 253 citations

Proteolytic Release of Soluble UL16-Binding Protein 2 from Tumor Cells

2006 • 232 citations

Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression

2004 • 202 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR

1999 • 191 citations

Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand

1999 • 188 citations

GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily

2005 • 173 citations

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity

2006 • 172 citations

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)

2006 • 157 citations

GITR/GITRL: More than an effector T cell co‐stimulatory system

2007 • 134 citations

Cancer immunoediting by GITR (glucocorticoid‐induced TNF‐related protein) ligand in humans: NK cell/tumor cell interactions

2007 • 97 citations

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

2008 • 71 citations

Soluble CD137 (4-1BB) Ligand Is Released Following Leukocyte Activation and Is Found in Sera of Patients with Hematological Malignancies

2001 • 67 citations

Bypassing tumor-associated immune suppression with recombinant adenovirus constructs expressing membrane bound or secreted GITR-L

2004 • 65 citations

Glucocorticoid-Induced TNF Receptor, a Costimulatory Receptor on Naive and Activated T Cells, Uses TNF Receptor-Associated Factor 2 in a Novel Fashion as an Inhibitor of NF-κB Activation

2005 • 59 citations

Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) and its Ligand (GITRL) in Atopic Dermatitis

2006 • 13 citations