Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

2002 • 1,325 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

The CD95(APO-1/Fas) DISC and beyond

2003 • 1,064 citations

TNF? and the TNF receptor superfamily: Structure-function relationship(s)

2000 • 983 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Apo2L/TRAIL and its death and decoy receptors

2003 • 851 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis

2003 • 738 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

2003 • 552 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Inhibition of Fas death signals by FLIPs

1998 • 531 citations

Tumor Necrosis Factor

2004 • 491 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

2002 • 432 citations

The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer

2003 • 399 citations

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

2004 • 374 citations

Targeting death receptors in cancer with Apo2L/TRAIL

2004 • 367 citations

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

2002 • 354 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

2003 • 288 citations

NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP

2004 • 255 citations

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

2002 • 247 citations

Following a TRAIL: Update on a ligand and its five receptors

2004 • 247 citations

Activation of the NF-κB pathway by Caspase 8 and its homologs

2000 • 234 citations

The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase

2000 • 225 citations

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors Signal NF-κB and JNK Activation and Apoptosis through Distinct Pathways

1999 • 217 citations

TRAIL-R as a Negative Regulator of Innate Immune Cell Responses

2004 • 205 citations

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

2001 • 202 citations

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

2004 • 200 citations

Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)

2000 • 183 citations

FADD is required for multiple signaling events downstream of the receptor Fas.

1999 • 179 citations

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

1997 • 168 citations

Selective Knockdown of the Long Variant of Cellular FLICE Inhibitory Protein Augments Death Receptor-mediated Caspase-8 Activation and Apoptosis

2005 • 152 citations

“Recruitment Signals” from Apoptotic Cells

2003 • 150 citations

Modulation of Tumor Necrosis Factor Apoptosis-inducing Ligand- induced NF-κB Activation by Inhibition of Apical Caspases

2001 • 148 citations

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

1998 • 144 citations

The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

2003 • 128 citations

Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

2003 • 117 citations

Fas Ligand Induces Cell-autonomous NF-κB Activation and Interleukin-8 Production by a Mechanism Distinct from That of Tumor Necrosis Factor-α

2004 • 103 citations

The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase

2003 • 97 citations

[57] Dye uptake method for assay of interferon activity

1981 • 35 citations

Reconstitution of Caspase-8 Sensitizes JB6 Cells to TRAIL

2000 • 20 citations