On the range of Hedgehog signaling

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1999 • 1,682 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Hedgehog signals regulate multiple aspects of gastrointestinal development

2000 • 821 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Sonic hedgehog is essential to foregut development

1998 • 685 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

1998 • 648 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

1998 • 631 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Cytonemes

1999 • 602 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

1995 • 542 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

1999 • 489 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

Control of compartment development by the engrailed gene in Drosophila

1975 • 429 citations

The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

1998 • 425 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants

1998 • 371 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish

1998 • 355 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Schwann Cell–Derived Desert Hedgehog Controls the Development of Peripheral Nerve Sheaths

1999 • 324 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

1999 • 307 citations

Compartments in the wing of Drosophila: A study of the engrailed gene

1976 • 297 citations

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning

1999 • 292 citations

Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death

1999 • 289 citations

The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium

2000 • 280 citations

Multiple left-right asymmetry defects in Shh ^−/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1

1999 • 263 citations

Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain

1996 • 255 citations

More Surprises in the Hedgehog Signaling Pathway

2000 • 219 citations

Prostate Development Requires Sonic Hedgehog Expressed by the Urogenital Sinus Epithelium

1999 • 217 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway

1999 • 207 citations

Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb

1998 • 179 citations

A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve

1999 • 178 citations

Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent

2000 • 175 citations

Ci: a complex transducer of the Hedgehog signal

1999 • 171 citations

Function for Hedgehog Genes in Zebrafish Retinal Development

2000 • 155 citations

Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

1997 • 149 citations

Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins

1999 • 147 citations

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1

1999 • 144 citations

Control of compartmental affinity boundaries by Hedgehog

1997 • 143 citations

Control of Muscle Cell-Type Specification in the Zebrafish Embryo by Hedgehog Signalling

1999 • 136 citations

A Retinal Axon Fascicle Uses Spitz, an EGF Receptor Ligand, to Construct a Synaptic Cartridge in the Brain of Drosophila

1998 • 127 citations

Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila

1997 • 125 citations

Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity

1999 • 122 citations

Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro.

1997 • 122 citations

Two Distinct Cell Populations in the Floor Plate of the Zebrafish Are Induced by Different Pathways

2000 • 113 citations

Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic InsultIn Vitro

1997 • 112 citations

Regulation of Left–Right Asymmetries in the Zebrafish by Shh and BMP4

1999 • 112 citations

Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly

1998 • 105 citations

Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals

1999 • 100 citations

Expression of ptc and gli genes in talpid 3 suggests bifurcation in Shh pathway*

1999 • 98 citations

ladybird determines cell fate decisions during diversification of Drosophila somatic muscles

1998 • 97 citations

In Vivo Regulation of Somite Differentiation and Proliferation by Sonic Hedgehog

1999 • 95 citations

Regulation and function oftinman during dorsal mesoderm induction and heart specification inDrosophila

1998 • 95 citations

New mouse models of congenital anorectal malformations

2000 • 92 citations

Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin to induce spinal motor neuron differentiation

2000 • 89 citations

The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila

1998 • 84 citations

Transcriptional regulation ofatonalrequired forDrosophilalarval eye development by concerted action of Eyes absent, Sine oculis and Hedgehog signaling independent of Fused kinase and Cubitus interruptus

2000 • 77 citations

Polarizing activity, Sonic hedgehog , and tooth development in embryonic and postnatal mouse

1996 • 75 citations

Compartmental organization of the Drosophila genital imaginal discs

1997 • 73 citations

The Heterotrimeric Protein Go Is Required for the Formation of Heart Epithelium in Drosophila

1999 • 69 citations

Control of chick tectum territory along dorsoventral axis by Sonic hedgehog

2000 • 69 citations

hedgehog and engrailed: pattern formation and polarity in the Drosophila abdomen

1999 • 64 citations

Wingless, Decapentaplegic and EGF Receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila

1999 • 63 citations

Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis

1997 • 61 citations

Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry

1997 • 59 citations

Polarizing activity,Sonic hedgehog, and tooth development in embryonic and postnatal mouse

1996 • 57 citations

Identification of mutations that cause cell migration defects in mosaic clones

1999 • 56 citations

Hedgehog activates the EGF receptor pathway during Drosophila head development

1999 • 55 citations

Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression

1998 • 49 citations

Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation.

1999 • 47 citations

Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc

2000 • 43 citations

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

1998 • 42 citations

Mutual antagonism between signals secreted by adjacent Wingless and Engrailed cells leads to specification of complementary regions of the Drosophila parasegment

1999 • 36 citations

Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo

1999 • 36 citations

hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNS

1996 • 33 citations

Role of sonic hedgehog in branchiomotor neuron induction in zebrafish

1998 • 30 citations

HedgehogandWinglessInduce Metameric Pattern in theDrosophilaVisceral Mesoderm

1998 • 29 citations