Hedgehog activates the EGF receptor pathway during Drosophila head development

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

1993 • 567 citations

The drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein

1993 • 443 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development

1997 • 372 citations

An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-β family in Drosophila

1991 • 330 citations

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

1995 • 312 citations

Cell determination strategies in the Drosophila eye

1997 • 308 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

1992 • 278 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

The argos gene encodes a diffusible factor that regulates cell fate decisions in the drosophila eye

1992 • 238 citations

argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop

1996 • 235 citations

The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm

1996 • 232 citations

wingless inhibits morphogenetic furrow movement in the Drosophila eye disc

1995 • 229 citations

Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila

1988 • 228 citations

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.

1996 • 218 citations

Multiple functions of the EGF receptor in Drosophila eye development

1998 • 210 citations

wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye

1995 • 210 citations

Repression of ci-D in posterior compartments of Drosophila by engrailed.

1990 • 205 citations

Altering the insertional specificity of a Drosophila transposable element.

1992 • 198 citations

Catching a Gli-mpse of Hedgehog

1997 • 198 citations

Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.

1994 • 195 citations

Development of the eye‐antenna imaginal disc and morphogenesis of the adult head in Drosophila melanogaster

1986 • 174 citations

Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation

1998 • 170 citations

Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

1989 • 163 citations

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

1994 • 155 citations

Hedgehog and beyond

1995 • 149 citations

Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes

1997 • 140 citations

There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor

1997 • 134 citations

Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors

1998 • 132 citations

Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog

1997 • 125 citations

Localization of transcripts from the wingless gene in whole Drosophila embryos

1988 • 111 citations

The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells

1997 • 109 citations

Signalling by hedgehog family proteins in Drosophila and vertebrate development

1995 • 107 citations

Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila

1997 • 103 citations

Molecular, Phenotypic, and Expression Analysis ofvein,a Gene Required for Growth of theDrosophilaWing Disc

1996 • 100 citations

hedgehog, wingless and orthodenticle specify adult head development in Drosophila

1996 • 100 citations

Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes

1997 • 97 citations

Functional intertwining of Dpp and EGFR signaling during Drosophilaendoderm induction

1998 • 95 citations

Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis

1997 • 95 citations

Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina

1998 • 90 citations

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis

1992 • 73 citations

Dissection of the faint little ball (fib) phenotype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm

1992 • 71 citations

orthodenticle regulation during embryonic head development in Drosophila

1996 • 63 citations

Imaginal discs can be recovered from cultured embryos mutant for the segment-polarity genes engrailed, naked and patched but not from wingless

1989 • 62 citations

Differential requirement for EGF-like ligands in Drosophila wing development

1997 • 41 citations

X-gal Staining of Drosophila Embryos Compatible with Antibody Staining or In Situ Hybridization

1998 • 15 citations

Genetic analysis of transdetermination in Drosophila

1984 • 9 citations