Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

1997 • 3,802 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Syndromes of the Head and Neck

1976 • 2,109 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD

1997 • 815 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Early stages of chick somite development

1995 • 781 citations

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

1997 • 712 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

1989 • 662 citations

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

1996 • 653 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Two myogenic lineages within the developing somite

1992 • 570 citations

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

1997 • 561 citations

Limb-somite relationship: origin of the limb musculature

1977 • 528 citations

Experimental analysis of the origin of the wing musculature in avian embryos

1977 • 520 citations

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.

1995 • 504 citations

Regulation of Pax-3 expression in the dermomyotome and its role in muscle development

1994 • 491 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Interplay between proliferation and differentiation within the myogenic lineage

1992 • 424 citations

Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4

1996 • 416 citations

Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue

1997 • 410 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification

1994 • 372 citations

Pax3 modulates expression of the c-Met receptor during limb muscle development.

1996 • 359 citations

Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog

1997 • 356 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Regulation of patched by sonic hedgehog in the developing neural tube.

1996 • 331 citations

Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish

1996 • 320 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Uncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development

1996 • 309 citations

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

1996 • 299 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development

1991 • 295 citations

Making muscle in mammals

1992 • 292 citations

Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina

1997 • 279 citations

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb

1996 • 265 citations

The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation

1992 • 216 citations

Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse

1996 • 215 citations

Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm

1996 • 212 citations

Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos

1992 • 210 citations

Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells

1995 • 209 citations

Determination of somite cells: independence of cell differentiation and morphogenesis

1988 • 204 citations

Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite

1995 • 194 citations

Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4

1997 • 183 citations

Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo

1983 • 177 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway

1996 • 176 citations

Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation

1995 • 165 citations

Making muscle in mammals

1992 • 152 citations

Hedgehog and beyond

1995 • 149 citations

A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material

1994 • 146 citations

Control of somite patterning by signals from the lateral plate.

1995 • 141 citations

Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice

1996 • 140 citations

Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb

1996 • 130 citations

Mouse limb muscle is determined in the absence of the earliest myogenic factor myf-5.

1994 • 128 citations

Myogenic specification in somites: induction by axial structures

1994 • 118 citations

Neural Tube and Notochord Promote in Vitro Myogenesis in Single Somite Explants

1995 • 101 citations

cAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD

1993 • 98 citations

Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos

1996 • 98 citations

Cyclic AMP-Dependent Protein Kinase Inhibits the Activity of Myogenic Helix-Loop-Helix Proteins

1992 • 95 citations

Autonomy of differentiation in avian brachial somites and the influence of adjacent tissues

1987 • 94 citations

Regulation and Function of SF/HGF during Migration of Limb Muscle Precursor Cells in Chicken

1996 • 92 citations

Temporal separation of the migration of distinct myogenic precursor populations into the developing chick wing bud

1984 • 74 citations

Myogenic Specification of Somites Is Mediated by Diffusible Factors

1995 • 64 citations

Etude de la migration des cellules somitiques dans le m�soderme somatopleural de l'�bauche de l'aile

1978 • 63 citations

Tissue and cellular patterning of the musculature in chick wings

1994 • 46 citations

Myogenic Determination Factor Expression in the Developing Avian Limb Bud: An RT–PCR Analysis

1996 • 33 citations

The 1996 Antarctic ozone hole

1996 • 16 citations

Deleted Work

1955 • 0 citations