Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

1993 • 719 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

Two myogenic lineages within the developing somite

1992 • 570 citations

Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

1991 • 548 citations

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.

1995 • 504 citations

Regulation of Pax-3 expression in the dermomyotome and its role in muscle development

1994 • 491 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1992 • 467 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Fate mapping and cell lineage analysis of Hensen’s node in the chick embryo

1991 • 433 citations

Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4

1996 • 416 citations

The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system

1990 • 383 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 356 citations

Mechanisms of vertebrate segmentation

1988 • 356 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain

1995 • 337 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

1993 • 313 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

1988 • 304 citations

Drosophila NK-homeobox genes.

1989 • 300 citations

Pax-6 Is First Expressed in a Region of Ectoderm Anterior to the Early Neural Plate: Implications for Stepwise Determination of the Lens

1994 • 292 citations

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

1992 • 268 citations

The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes

1991 • 259 citations

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

1996 • 245 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation

1992 • 216 citations

Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm

1996 • 212 citations

Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite

1995 • 194 citations

The ventralizing effect of the notochord on somite differentiation in chick embryos

1993 • 186 citations

Tissue-specific expression of murineNkx3.1 in the male urogenital system

1997 • 178 citations

Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo

1983 • 177 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Molecular basis of morphogenesis

1993 • 151 citations

Control of somite patterning by signals from the lateral plate.

1995 • 141 citations

The Expression Pattern of the Chick Homeobox Gene gMHox Suggests a Role in Patterning of the Limbs and Face and in Compartmentalization of Somites

1994 • 131 citations

Local signalling in dermomyotomal cell type specification

1992 • 129 citations

Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite

1993 • 121 citations

Myogenic specification in somites: induction by axial structures

1994 • 118 citations

Neural Tube and Notochord Promote in Vitro Myogenesis in Single Somite Explants

1995 • 101 citations

Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos

1996 • 98 citations

Autonomy of differentiation in avian brachial somites and the influence of adjacent tissues

1987 • 94 citations

Neural control of early myogenic differentiation in cultures of mouse somites

1986 • 80 citations

Myogenic Specification of Somites Is Mediated by Diffusible Factors

1995 • 64 citations

Distinct Signal/Response Mechanisms Regulatepax1andQmyoDActivation in Sclerotomal and Myotomal Lineages of Quail Somites

1997 • 49 citations

Effects of the TWis mutation on notochord formation and mesodermal patterning

1995 • 36 citations