A New Role of Ran GTPase

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

1996 • 978 citations

The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases

1997 • 939 citations

Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

1995 • 851 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

Identification of γ-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans

1989 • 613 citations

A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly

1996 • 565 citations

Force Generation by Microtubule Assembly/Disassembly in Mitosis and Related Movements

1995 • 531 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

1995 • 471 citations

NTF2 mediates nuclear import of Ran

1998 • 459 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

1995 • 398 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

THE CENTROSOME AND CELLULAR ORGANIZATION

1994 • 361 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

MPF localization is controlled by nuclear export

1998 • 340 citations

Transport into and out of the cell nucleus

1998 • 332 citations

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1998 • 331 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

1999 • 308 citations

Self-Organization of Microtubule Asters Induced in Xenopus Egg Extracts by GTP-Bound Ran

1999 • 305 citations

Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage

1998 • 298 citations

The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller

1998 • 298 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

1995 • 247 citations

A yeast mutant which accumulates precursor tRNAs

1978 • 231 citations

Karyopherins and kissing cousins

1998 • 220 citations

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

1990 • 202 citations

The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p

1998 • 197 citations

A molecular marker for centriole maturation in the mammalian cell cycle.

1995 • 197 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2

1998 • 193 citations

When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin

1998 • 188 citations

RNA Export

1995 • 181 citations

Molecular components of the centrosome

1993 • 164 citations

Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the ras-family GTPase ran 1 1Edited by I. B. Holland

1998 • 151 citations

Two-way trafficking with Ran

1998 • 142 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

1994 • 138 citations

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

1994 • 125 citations

Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport

1995 • 125 citations

NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.

1993 • 119 citations

Xgrip109: A γ Tubulin–Associated Protein with an Essential Role in γ Tubulin Ring Complex (γTuRC) Assembly and Centrosome Function

1998 • 112 citations

The search for the primary function of the Ran GTPase continues

1996 • 111 citations

Modulation of microtubule dynamics during the cell cycle

1996 • 107 citations

A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export

1998 • 98 citations

Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.

1996 • 85 citations

Influence of M-phase chromatin on the anisotropy of microtubule asters.

1996 • 85 citations

The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1.

1991 • 76 citations

RCC1 in the Ran Pathway

1996 • 71 citations

The Cell Center at 100

1997 • 68 citations

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP–Gsp1p, the Saccharomyces cerevisiae Ran homologue

1998 • 65 citations

Yrb2p, a Nup2p-Related Yeast Protein, Has a Functional Overlap with Rna1p, a Yeast Ran-GTPase-Activating Protein

1997 • 64 citations

DNA-binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication

1992 • 59 citations

Human RanBP3, a group of nuclear RanGTP binding proteins¹

1998 • 55 citations

Yrb2p Is a Nuclear Protein That Interacts with Prp20p, a Yeast Rcc1 Homologue

1997 • 45 citations

Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts

1997 • 41 citations

Disruption of the YRB2 Gene Retards Nuclear Protein Export, Causing a Profound Mitotic Delay, and Can Be Rescued by Overexpression of XPO1/CRM1

1999 • 39 citations

Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p

1998 • 29 citations

Role of chromosomes in assembly of meiotic and mitotic spindles

1997 • 14 citations