The Ran GTPase: Theme and Variations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

Transport into and out of the Nucleus

2001 • 877 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

2001 • 592 citations

A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly

1996 • 565 citations

Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts

2002 • 526 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex

1998 • 455 citations

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

1995 • 398 citations

Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

2001 • 374 citations

PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by Phosphorylation

2000 • 371 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

2001 • 318 citations

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

2002 • 290 citations

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

2001 • 261 citations

GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly

2000 • 255 citations

RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

1997 • 250 citations

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

1995 • 247 citations

Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly

2001 • 243 citations

Importin 13: a novel mediator of nuclear import and export

2001 • 240 citations

Chromatin Docking and Exchange Activity Enhancement of RCC1 by Histones H2A and H2B

2001 • 233 citations

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

2001 • 221 citations

Systems Analysis of Ran Transport

2002 • 204 citations

Chromatin-Independent Nuclear Envelope Assembly Induced by Ran GTPase in Xenopus Egg Extracts

2000 • 199 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2

1998 • 193 citations

Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p

1998 • 186 citations

Running on Ran

2001 • 177 citations

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

1999 • 145 citations

Mutants in a yeast Ran binding protein are defective in nuclear transport.

1995 • 144 citations

The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo Proteins

2001 • 140 citations

Ran-Binding Protein 3 Is a Cofactor for Crm1-Mediated Nuclear Protein Export

2001 • 139 citations

Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

2001 • 126 citations

NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.

1993 • 119 citations

Nuclear Import of the TATA-binding Protein: Mediation by the Karyopherin Kap114p and a Possible Mechanism for Intranuclear Targeting

1999 • 118 citations

The GTPase Ran Regulates Chromosome Positioning and Nuclear Envelope Assembly In Vivo

2002 • 112 citations

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates

2001 • 112 citations

The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.

1995 • 105 citations

Two distinct classes of Ran-binding sites on the nucleoporin Nup-358

1999 • 96 citations

Role of Importin-β in the Control of Nuclear Envelope Assembly by Ran

2002 • 83 citations

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

2000 • 79 citations

Roles of Ran–GTP and Ran–GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

2001 • 69 citations

Ran Binds to Chromatin by Two Distinct Mechanisms

2002 • 64 citations

Ran-binding Protein 3 Links Crm1 to the Ran Guanine Nucleotide Exchange Factor

2002 • 56 citations

Ran Localizes around the Microtubule Spindle In Vivo during Mitosis in Drosophila Embryos

2002 • 49 citations

Nuclear transport: Randy couples

1999 • 27 citations

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