Biological and Clinical Significance of Cathepsin D in Breast Cancer Metastasis

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

The Structure and Function of the Aspartic Proteinases

1990 • 637 citations

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

1995 • 428 citations

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

1995 • 359 citations

Breast Cancer-Associated pS2 Protein: Synthesis and Secretion by Normal Stomach Mucosa

1988 • 341 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Cathepsin D. Purification of isoenzymes from human and chicken liver

1970 • 273 citations

Steps in tumor metastasis: new concepts from intravital videomicroscopy

1995 • 268 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

1987 • 209 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

Hormone-dependent regulation of BRCA1 in human breast cancer cells.

1995 • 178 citations

Characterization of very acidic phagosomes in breast cancer cells and their association with invasion

1994 • 165 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.

1993 • 149 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.

1994 • 145 citations

Compartmentalized signal transduction by receptor tyrosine kinases

1995 • 144 citations

MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

1991 • 142 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

Biosynthesis of lysosomal endopeptidases

1989 • 128 citations

Characterization of the proximal estrogen-responsive element of human cathepsin D gene.

1994 • 127 citations

Effects of antiestrogens on the estrogen-regulated pS2 RNA and the 52- and 160-kilodalton proteins in MCF7 cells and two tamoxifen-resistant sublines.

1984 • 120 citations

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.

1990 • 116 citations

The selectivity of Cathepsin D Suggests an Involvement of the Enzyme in the Generation of T-cell Epitopes

1989 • 105 citations

Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.

1995 • 99 citations

Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain

1994 • 95 citations

Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.

1992 • 93 citations

Cloning and Sequencing of the 52K Cathepsin D Complementary Deoxyribonucleic Acid of MCF7 Breast Cancer Cells and Mapping on Chromosome 11

1988 • 91 citations

Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal Proenzymes

1991 • 90 citations

Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.

1992 • 90 citations

Cathepsin D and breast cancer

1996 • 86 citations

Comparative analysis of cathepsin l, cathepsin d, and collagenase messenger rna expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization

1995 • 81 citations

Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer

1989 • 79 citations

Molecular Organization of the Human Cathepsin D Gene

1991 • 75 citations

Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

1994 • 71 citations

Proteolysis of Glucagon within Hepatic Endosomes by Membrane-associated Cathepsins B and D

1995 • 71 citations

Anti‐proliferative and anti‐estrogenic effects of ICI 164,384 and ICI 182,780 in 4‐OH‐tamoxifen‐resistant human breast‐cancer cells

1994 • 69 citations

Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.

1995 • 66 citations

Specific Mannose-6-Phosphate Receptor-Independent Sorting of Pro-Cathepsin D in Breast Cancer Cells

1994 • 64 citations

Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: Correlation with cytosolic assay

1994 • 64 citations

Cathepsin D inactivates cysteine proteinase inhibitors cystatins

1988 • 61 citations

Characterization of the proximal estrogen-responsive element of human cathepsin D gene

1994 • 59 citations

Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction—Single strand conformational polymorphism analysis and possible consequences in cancer cells

1994 • 55 citations

Phagocytic Tumour Cells

1973 • 41 citations

Expression of Cathepsin D in Primary and Metastatic Human Melanoma and Dysplastic Nevi

1995 • 41 citations

Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells

1995 • 37 citations

Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: Relative prognostic value versus total cathepsin D

1993 • 33 citations

Quantitative Immunohistochemical Determination of Cathepsin D Levels in Prostatic Carcinoma Biopsies:Correlation with Tumor Grade, Stage, PSA Level, and DNA Ploidy Status

1995 • 31 citations

Cellular localisation byin situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer

1996 • 30 citations

Purification and characterization of a cathepsin D protease from bovine chromaffin granules

1992 • 30 citations

Cathepsin D Content in Colorectal Cancer

1995 • 28 citations

Mitogenic activity of procathepsin D purified from conditioned medium of breast‐cancer cells by affinity chromatography on pepstatinyl agarose

1994 • 26 citations

Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer

1991 • 24 citations

Phagocytic capacity of invasive malignant cells in three-dimensional culture

1980 • 23 citations