Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain

The determination of enzyme inhibitor constants

1953 • 4,050 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

The Cell Biology of Antigen Processing and Presentation

1991 • 349 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro

1991 • 271 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

Interaction of human cathepsin D with the inhibitor pepstatin

1976 • 150 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Purification and Tissue Distribution of Rat Cathepsin L1

1986 • 136 citations

Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.

1990 • 113 citations

Cathepsin D of Rat Spleen Affinity Purification and Properties of Two Types of Cathepsin D

1979 • 107 citations

Role of cathepsin D in antigen presentation of ovalbumin.

1992 • 93 citations

Participation of cathepsin B in processing of antigen presentation to MHC class II

1993 • 87 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

1991 • 75 citations

The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases

1980 • 75 citations

A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells.

1986 • 74 citations

Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains.

1991 • 68 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.

1988 • 61 citations

Differential sensitivity of specific and nonspecific antigen-presentation by B cells to a protein synthesis inhibitor.

1990 • 44 citations

Two-step affinity-chromatographic purification of cathepsin D from pig myometrium with high yield

1981 • 43 citations

Crystallization and amino acid composition of cathepsin B from rat liver lysosomes

1978 • 25 citations