Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction—Single strand conformational polymorphism analysis and possible consequences in cancer cells

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

1978 • 373 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium

1987 • 237 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

Isolation of Two Human Tumor Epithelial Cell Lines From Solid Breast Carcinomas<xref ref-type="fn" rid="FN1">2</xref>

1978 • 191 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

Lysosomal Enzymes and Their Receptors

1986 • 174 citations

Protocols for an improved detection of point mutations by SSCP

1991 • 170 citations

Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2

1982 • 163 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells

1987 • 118 citations

Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors

1989 • 102 citations

In Vitro Growth Promotion of Human Mammary Carcinoma Cells by Steroid Hormones, Tamoxifen, and Prolactin23

1984 • 92 citations

Cloning and Sequencing of the 52K Cathepsin D Complementary Deoxyribonucleic Acid of MCF7 Breast Cancer Cells and Mapping on Chromosome 11

1988 • 91 citations

Somatic mutations and human breast cancer. A Status Report

1992 • 90 citations

Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal Proenzymes

1991 • 90 citations

Molecular Organization of the Human Cathepsin D Gene

1991 • 75 citations

Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

1994 • 71 citations

Cytogenetic Studies of Human Breast Cancer Lines: MCF-7 and Derived Variant Sublines

1983 • 44 citations

Release of estrogen-induced glycoprotein with a molecular weight of 52,000 by breast cancer cells in primary culture.

1983 • 39 citations

Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: Relative prognostic value versus total cathepsin D

1993 • 33 citations

Suppression of tumorigenesis by the breast cancer cell line MCF-7 following transfer of a normal human chromosome 11.

1992 • 16 citations