MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Angiogenic Factors

1987 • 3,702 citations

The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous System

1958 • 1,786 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

The Use of the Avidin‐Biotin Complex as a Tool in Molecular Biology

1980 • 611 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

The fibroblast growth factor family.

1990 • 219 citations

Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

1987 • 209 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

1988 • 126 citations

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.

1990 • 116 citations

Effect of estradiol on the ultrastructure of the MCF7 human breast cancer cells in culture.

1982 • 107 citations

Mechanisms of normal and malignant breast epithelial growth regulation

1989 • 65 citations

Growth-stimulatory effect of androgen-induced autocrine growth factor(s) secreted from Shionogi carcinoma 115 cells on androgen-unresponsive cancer cells in a paracrine mechanism.

1988 • 50 citations

Binding, internalization, and degradation of basic fibroblast growth factor in human microvascular endothelial cells

1989 • 45 citations

Biochemical comparative studies between eye- and brain-derived growth factors

1987 • 31 citations

Internalization and Limited Processing of Basic Fibroblast Growth Factor on Chinese Hamster Lung Fibroblasts

1989 • 24 citations