Cathepsin D and breast cancer

Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy:133 Randomised Trials involoving 31 000 Recurrences and 24 000 Deaths Among 75 000 Women (Summary)

1993 • 967 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

1993 • 269 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

1994 • 247 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

1990 • 150 citations

Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.

1993 • 149 citations

MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

1991 • 142 citations

The role of cathepsin D in the invasiveness of human breast cancer cells.

1993 • 132 citations

Characterization of the proximal estrogen-responsive element of human cathepsin D gene.

1994 • 127 citations

Multiparametric Prognostic Evaluation of Biological Factors in Primary Breast Cancer

1992 • 125 citations

Immunolocalization of cathepsin D in normal and neoplastic human tissues.

1986 • 124 citations

Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D.

1994 • 121 citations

Interactions of Cathepsin-D and Insulin-Like Growth Factor-II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast CancerCells and Possible Consequences on Mitogenic Activity of IGF-II

1990 • 119 citations

Cathepsin D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer.

1993 • 118 citations

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells

1987 • 118 citations

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.

1990 • 116 citations

The selectivity of Cathepsin D Suggests an Involvement of the Enzyme in the Generation of T-cell Epitopes

1989 • 105 citations

The 52-kDa estrogen-induced protein secreted by MCF7 cells is a lysosomal acidic protease

1986 • 98 citations

Mitogenic function of human procathepsin D: the role of the propeptide

1994 • 97 citations

Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.

1992 • 93 citations

Cloning and Sequencing of the 52K Cathepsin D Complementary Deoxyribonucleic Acid of MCF7 Breast Cancer Cells and Mapping on Chromosome 11

1988 • 91 citations

Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis.

1993 • 91 citations

Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal Proenzymes

1991 • 90 citations

Modulation of the proliferative response of breast cancer cells to growth factors by oestrogen

1992 • 89 citations

Characterization of monoclonal antibodies to the estrogen-regulated Mr 52,000 glycoprotein and their use in MCF7 cells.

1985 • 89 citations

Estradiol induced proteins in the MCF7 human breast cancer cell line

1979 • 85 citations

Age-related increase in a cathepsin D-like protease that degrades brain microtubule-associated proteins

1987 • 80 citations

Molecular Organization of the Human Cathepsin D Gene

1991 • 75 citations

A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol

1993 • 74 citations

Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.

1994 • 71 citations

Immunoenzymatic assay of Mr 52,000 cathepsin D in 182 breast cancer cytosols: low correlation with other prognostic parameters.

1988 • 71 citations

Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene.

1992 • 69 citations

Evaluation of cathepsin D as a prognostic factor in breast cancer

1993 • 68 citations

Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells

1989 • 66 citations

Prognostic significance of cathepsin‐D expression in node‐positive breast carcinoma: An immunohistochemical study

1993 • 65 citations

Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: Correlation with cytosolic assay

1994 • 64 citations

Prognostic significance of cathepsin-D in patients with breast cancer

1993 • 63 citations

Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.

1992 • 61 citations

Cathepsin D by western blotting and immunohistochemistry: failure to confirm correlations with prognosis in node-negative breast cancer.

1994 • 60 citations

Characterization of the proximal estrogen-responsive element of human cathepsin D gene

1994 • 59 citations

Effect of human procathepsin D on proliferation of human cell lines

1994 • 57 citations

Stromal cell cathepsin D expression and long-term survival in breast cancer

1995 • 55 citations

Prognostic value of total cathepsin D in breast tumors

1991 • 55 citations

Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer

1993 • 54 citations

Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings

1991 • 54 citations

Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

1991 • 47 citations

Immunohistochemical distribution of the 52-kDa protein in mammary tumors: A marker associated with cell proliferation rather than with hormone responsiveness

1987 • 45 citations

Cathepsin D in primary breast carcinoma: Adverse prognosis is associated with expression of cathepsin D in stromal cells

1995 • 41 citations

Cathepsin D gene of human MCF7 cells contains estrogen-responsive sequences in its 5′ proximal flanking region

1991 • 40 citations

Two-site immunoenzymometric assay for the 52-kDa cathepsin D in cytosols of breast cancer tissues.

1989 • 37 citations

Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene

1992 • 34 citations

The relative prognostic significance of total cathepsin D and HER‐2/neu oncogene amplification in breast cancer

1994 • 33 citations

[Cathepsin D: an independent prognostic factor in cancer of the breast].

1990 • 32 citations

The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point

1993 • 31 citations

Immunostaining of cathepsin D in breast cancer: Quantification by computerised image analysis and correlation with cytosolic assay

1992 • 31 citations

Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer

1994 • 31 citations

Quality control of cathepsin-D measurement by the EORTC receptor study group

1992 • 29 citations

Prognostic value of Cathepsin D expression in breast cancer: Immunohistochemical assessment and correlation with radiometric assay

1994 • 27 citations

PS2 in breast cancer – alternative or complementary tool to steroid receptor status? Evaluation of 446 cases

1993 • 27 citations

Mitogenic activity of procathepsin D purified from conditioned medium of breast‐cancer cells by affinity chromatography on pepstatinyl agarose

1994 • 26 citations

Purification and first characterization of the secreted and cellular 52-kDa proteins regulated by estrogens in human-breast cancer cells

1986 • 25 citations

Cloning, sequence and expression of rat cathepsin D

1990 • 25 citations

Nonhuman cells correctly sort and process the human lysosomal enzyme cathepsin D

1989 • 23 citations

Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of cathepsin D in human breast cancer cells.

1988 • 23 citations

Molecular cloning of mouse cathepsin D

1990 • 22 citations

Nucleotide sequence of a cDNA encoding mouse cathepsin D

1990 • 19 citations

Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry

1992 • 14 citations

A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.

1989 • 12 citations

In vivo stimulation by tamoxifen of cathepsin D RNA level in breast cancer

1994 • 12 citations

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