Chemoprotection of normal tissues by transfer of drug resistance genes

Bone marrow transplant

1989 • 3,423 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

1993 • 949 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

1990 • 470 citations

GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER

1995 • 469 citations

Mechanisms of carcinogenesis induced by alkylating agents

1985 • 461 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Tissue-Specific Targeting of Retroviral Vectors Through Ligand-Receptor Interactions

1994 • 424 citations

Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells

1994 • 418 citations

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

1994 • 415 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

[40] Use of retroviral vectors for gene transfer and expression

1993 • 412 citations

Expression of CD34 by Solitary Fibrous Tumors of the Pleura, Mediastinum, and Lung

1994 • 368 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Molecular cloning and chromosomal localization of the human thrombopoietin gene

1994 • 237 citations

Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells

1995 • 237 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

Growth and Differentiation in the Hemopoietic System

1987 • 220 citations

Recombinant Human Erythropoietin Therapy for Anemic Cancer Patients on Combination Chemotherapy

1993 • 207 citations

The use of DNA viruses as vectors for gene therapy.

1994 • 206 citations

Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells.

1990 • 203 citations

Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery.

1995 • 201 citations

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1993 • 195 citations

Foamy virus vectors

1996 • 179 citations

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

1992 • 178 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

An Inhibitor of Stem Cell Proliferation in Normal Bone Marrow

1976 • 160 citations

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

1991 • 152 citations

Expression of a Human Multidrug Resistance cDNA (MDR1) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-Induced Leukopenia

1989 • 151 citations

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

1994 • 147 citations

Stem cell factor, interleukin-3, and interleukin-6 promote retroviral- mediated gene transfer into murine hematopoietic stem cells

1992 • 147 citations

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

1993 • 143 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 141 citations

Transfer and expression of the human multiple drug resistance gene in human CD34+ cells

1994 • 137 citations

Ligand-directed retroviral targeting of human breast cancer cells.

1995 • 128 citations

Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor

1994 • 126 citations

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.

1986 • 125 citations

Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

1995 • 123 citations

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells

1995 • 122 citations

Secondary Malignancies Following Cancer Chemotherapy

1994 • 115 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 114 citations

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

1996 • 113 citations

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

1985 • 113 citations

CD34 immunoexpression in stromal tumours of the gastrointestinal tract and in mesenteric fibromatoses

1994 • 112 citations

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.

1989 • 112 citations

Receptor-Mediated Gene Transfer into Human T LymphocytesviaBinding of DNA/CD3 Antibody Particles to the CD3 T Cell Receptor Complex

1995 • 110 citations

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

1992 • 105 citations

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

1992 • 98 citations

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice [published erratum appears in Blood 1995 Apr 1;85(7):1983]

1995 • 96 citations

Tissue-specific targeting of gytokine unresponsiveness in transgenic mice

1995 • 94 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 93 citations

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1992 • 92 citations

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

1994 • 91 citations

Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model.

1994 • 91 citations

An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer

1992 • 87 citations

Retroviral Vectors

1992 • 87 citations

Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study

1995 • 83 citations

Retroviral Coexpression of a Multidrug Resistance Gene (MDR1) and Humanα-Galactosidase A for Gene Therapy of Fabry Disease

1995 • 83 citations

Retroviral Mediated Transfer of the Human Multidrug Resistance Gene (MDR-1) into Hematopoietic Stem Cells During Autologous Transplantation after Intensive Chemotherapy for Metastatic Breast Cancer. National Institutes of Health, Bethesda, Maryland

1994 • 80 citations

An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer

1992 • 80 citations

Clinical and in vitro effects of recombinant human erythropoietin in patients receiving intensive chemotherapy for small-cell lung cancer.

1995 • 77 citations

Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood.

1995 • 73 citations

High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas.

1993 • 69 citations

A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

1993 • 69 citations

A Phase 1 Study, in Cystic Fibrosis Patients, of the Safety, Toxicity, and Biological Efficacy of a Single Administration of a Replication Deficient, Recombinant Adenovirus Carrying the cDNA of the Normal Cystic Fibrosis Transmembrane Conductance Regulator Gene in the Lung. National Institutes of Health, Bethesda, Maryland

1995 • 68 citations

Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene

1995 • 59 citations

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

1995 • 59 citations

On the quantitative relationship between O6-ethylguanine residues, in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer− human tumor cell line

1994 • 58 citations

Biological Consequences of Reactions with DNA: Role of Specific Lesions

1990 • 58 citations

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

1993 • 58 citations

Human MDR Gene Transfer in Patients with Advanced Cancer. Columbia University, New York, New York

1994 • 53 citations

Expression in mammalian cells of a truncated Escherichia coli gene coding for O⁶-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents

1986 • 51 citations

Genetic toxicity and potential carcinogenicity of taxol

1994 • 50 citations

Identification and Characterization of a Functional Promoter Region in the Human Eosinophil IL-5 Receptor α Subunit Gene

1995 • 50 citations

The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture

1992 • 48 citations

Transfection of murine multi-potent haemopoietic stem cells with an E.coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents

1988 • 47 citations

Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil

1994 • 47 citations

O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.

1995 • 47 citations

Retrovirus‐mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells

1994 • 46 citations

Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells

1995 • 45 citations

Glutathione-related enzymes, glutathione and multidrug resistance

1993 • 44 citations

Long-term protection of hematopoiesis against the cytotoxic effects of multiple doses of nitrosourea by retrovirus-mediated expression of human O6-alkylguanine-DNA-alkyltransferase

1996 • 44 citations

Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene.

1995 • 43 citations

Human APC gene expression in rodent colonic epithelium in vivo using liposomal gene delivery

1994 • 43 citations

Functional characterization of the promoter for the gene encoding human eosinophil peroxidase.

1994 • 43 citations

O⁶-Methylguanine-induced replication blocks

1995 • 41 citations

Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents.

1986 • 37 citations

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

1994 • 37 citations

Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.

1995 • 32 citations

Chinese hamster cells harbouring the Escherichia coli O⁶-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

1986 • 30 citations

Recombinant Human Erythropoietin Treatment in Elderly Cancer Patients with Cisplatin–Associated Anemia

1995 • 29 citations

Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase.

1993 • 27 citations

Transduction of NIH 3T3 cells with a retrovirus carrying both human MDR1 and glutathione S-transferase pi produces broad-range multidrug resistance.

1995 • 26 citations

Bicistronic and Two-Gene Retroviral Vectors for UsingMDR1 as a Selectable Marker and a Therapeutic Gene

1996 • 25 citations

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice [published erratum appears in Blood 1995 Apr 1;85(7):1983]

1995 • 23 citations

Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.

1996 • 22 citations

Harvey Murine Sarcoma Virus/MDR1 Retrovital Vectors: Efficient Virus Production and Foreign Gene Transduction Using MDR1 as a Selectable Marker

1995 • 22 citations

Transduction of MDR1 into human and mouse haemopoietic progenitor cells: use of rhodamine (Rhl23) to determine transduction frequency and in vivo selection

1995 • 20 citations

Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer. Selection of the most acceptable regimen to induce maximal tumor response and investigation of the optimal time to collect peripheral blood progenitor cells for haematological rescue after high-dose consolidation chemotherapy.

1994 • 20 citations

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.

1992 • 19 citations

High-dose therapy with autologous bone marrow transplantation for the treatment of solid tumors

1994 • 16 citations

Another Jekyll and Hyde story?

1996 • 14 citations

Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer

1994 • 14 citations

In vivo models of P-glycoprotein-mediated multidrug resistance

1994 • 14 citations

Phase II studies of mitozolomide in melanoma, lung and ovarian cancer

1989 • 12 citations

Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation

1995 • 9 citations

The iatrogenic leukaemias induced by radio-and/or chemotherapy

1987 • 7 citations

Mobilization of CD34‐positive tumour cells in a patient with testicular mixed germ cell tumour

1995 • 5 citations

Multiple drug resistance, the MDR gene, and the law of maximum perversity as it applies to oncology: An hypothesis

1994 • 4 citations

Colony-stimulating factors in the clinic

1992 • 3 citations

Growth Factor‐Assisted Chemotherapy—The Manchester Experience

2007 • 3 citations

DNA cross-linking by chloroethylating agents.

1986 • 2 citations