Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Amplification and analysis of DNA sequences in single human sperm and diploid cells

1988 • 685 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Effect of internal viral sequences on the utility of retroviral vectors

1987 • 351 citations

Cellular and developmental properties of fetal hematopoietic stem cells

1990 • 317 citations

Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer

1983 • 296 citations

Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma.

1990 • 275 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.

1986 • 191 citations

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells.

1990 • 149 citations

Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures

1985 • 144 citations

Comparison of the Effects of Growth Factors on Retroviral Vector-Mediated Gene Transfer and the Proliferative Status of Human Hematopoietic Progenitor Cells

1990 • 133 citations

Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors

1992 • 125 citations

The L4F3 antigen is expressed by unipotent and multipotent colony- forming cells but not by their precursors

1986 • 119 citations

Expression of human adenosine deaminase in murine hematopoietic cells.

1988 • 112 citations

Metabolically inactive 3T3 cells can substitute for marrow stromal cells to promote the proliferation and development of multipotent haemopoietic stem cells

1987 • 110 citations

Correction of glucocerebrosidase deficiency after retroviral-mediated gene transfer into hematopoietic progenitor cells from patients with Gaucher disease.

1990 • 93 citations

Gene transfer into normal human hematopoietic cells using in vitro and in vivo assays

1991 • 82 citations

Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells.

1989 • 73 citations

Surface membrane-associated regulation of cell assembly, differentiation, and growth

1991 • 61 citations

Improved retroviral transfer of genes into canine hematopoietic progenitor cells kept in long-term marrow culture

1989 • 55 citations

Leukemia inhibitory factor improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo.

1991 • 50 citations

Use of scid mice to identify and quantitate lymphoid-restricted stem cells in long-term bone marrow cultures

1989 • 47 citations

Characterization of recombinant helper retroviruses from moloney-based vectors in ecotropic and amphotropic packaging cell lines

1991 • 43 citations

Clinical application of Percoll gradient-separated bone marrow.

1987 • 20 citations