Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

Hypervariable ‘minisatellite’ regions in human DNA

1985 • 3,789 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Microsatellites for linkage analysis of genetic traits

1992 • 440 citations

Triplet repeat mutations in human disease

1992 • 417 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

1987 • 353 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

1987 • 161 citations

Molecular characterization of a spontaneously generated new allele at a VNTR locus: No exchange of flanking DNA sequence*1

1988 • 148 citations

Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals

1992 • 138 citations

Evidence for increased recombination near the human insulin gene: implication for disease association studies.

1986 • 113 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1985 • 100 citations

HLA and insulin gene associations with IDDM

1989 • 93 citations

Organization of the human genes for insulin‐like growth factors I and II

1986 • 88 citations

Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5‘ flanking region of the human insulin gene

1992 • 86 citations

The human insulin gene linked polymorphic region exhibits an altered DNA structure

1992 • 86 citations

Improved yields of long PCR products using gene 32 protein

1990 • 82 citations

Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.

1988 • 62 citations

Linkage disequilibrium in the human insulin/insulin-like growth factor II region of human chromosome II.

1988 • 48 citations

Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3

1992 • 48 citations

A variant insulin promoter in non-insulin-dependent diabetes mellitus.

1992 • 44 citations

DNA INSERTION SEQUENCES NEAR THE INSULIN GENE AFFECT GLUCOSE REGULATION

1982 • 42 citations

Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage.

1988 • 42 citations

The insulin gene and susceptibility to IDDM

1989 • 40 citations

Variability of the Insulin Gene in American Blacks With NIDDM: Analysis by Single-Strand Conformational Polymorphisms

1992 • 38 citations

Islet β-Cell Function and Polymorphism in the 5′-Flanking Region of the Human Insulin Gene

1985 • 34 citations

DNA polymorphic haplotypes on the short arm of chromosome 11 and the inheritance of type I diabetes mellitus.

1986 • 18 citations

HLA-DR and the 5′ insulin gene polymorphism in insulin-dependent diabetes

1991 • 15 citations

The Molecular Genetics of Diabetes Mellitus

2007 • 14 citations

Human tyrosine hydroxylase (TH) genomic fragment (pHGTH4) identifies a PstI polymorphism

1988 • 12 citations

Restriction fragment polymorphisms of the HLA‐DR, HLA‐DQ, and insulin gene regions in IDDM: The GAW5 data

1989 • 9 citations