Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.

1988 • 378 citations

Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.

1975 • 290 citations

HL‐A and Disease Associations ‐ A Survey

1975 • 280 citations

The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association

1983 • 251 citations

HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus

1981 • 231 citations

Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.

1986 • 193 citations

Age-Corrected Empirical Genetic Risk Estimates for First-Degree Relatives of IDDM Patients

1987 • 165 citations

Transcomplementation of HLA Genes in IDDM: HLA-DQ α and β-Chains Produce Hybrid Molecules in DR3/4 Heterozygotes

1987 • 158 citations

New HLA DNA polymorphisms associated with autoimmune diseases

1986 • 135 citations

A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

1985 • 134 citations

Gene dosage and susceptibility to insulin‐dependent diabetes

1980 • 117 citations

Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

1984 • 113 citations

HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus.

1984 • 107 citations

Only one DQ-beta restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes.

1986 • 100 citations

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1985 • 100 citations

HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes

1986 • 99 citations

HLA Genotypic Study of Insulin-dependent Diabetes: The Excess of DR3/DR4 Heterozygotes Allows Rejection of the Recessive Hypothesis

1983 • 97 citations

A two locus model for juvenile diabetes

1980 • 97 citations

Can Future Type I Diabetes Be Predicted? A Study in Families of Affected Children

1982 • 87 citations

Diabetes mellitus among first‐ and second‐deǵree relatives of early onset diabetics

1978 • 84 citations

HLA haplotype study of 53 juvenile insulin‐dependent diabetic (I.D.D.) families

1982 • 79 citations

Juvenile-onset Diabetes: HLA-A, -B, -C, and -DR Alloantigens

1978 • 76 citations

HLA Genotype studies in juvenile insulin-dependent diabetes

1980 • 74 citations

HLA‐DP antigens are involved in the susceptibility to multiple sclerosis

1988 • 71 citations

A three‐allele model for heterogeneity of juvenile onset insulin‐dependent diabetes

1980 • 71 citations

Insulin-dependent diabetes—Associated HLA-D region encoded determinants

1985 • 68 citations

HLA genotype distribution and genetic models of insulin‐dependent diabetes mellitus

1981 • 66 citations

A DR3-related DX? gene polymorphism strongly associates with insulin-dependent diabetes mellitus

1986 • 58 citations

The affected sib method. IV. Sib trios

1985 • 53 citations

HLA-D–related (DRw) Antigens in Juvenile Diabetes Mellitus

1979 • 47 citations

HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2 IDDM patients belong to one of these clusters

1986 • 45 citations

Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients

1988 • 43 citations

Empirical Risk for Insulin-dependent Diabetes (IDD) in Sibs: Further Definition of Genetic Heterogeneity

1982 • 43 citations

An epidemiological study of childhood diabetes affecting two or more siblings

1980 • 43 citations

Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system.

1983 • 43 citations

Three-Allele Synergistic Mixed Model for Insulin-Dependent Diabetes Mellitus

1986 • 43 citations

Islet Cell Antibodies and Histocompatibility Antigens (HLA) in Insulin-Dependent Diabetics and Their First-Degree Relatives

1982 • 42 citations

A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system

1984 • 42 citations

HLA-DR effects in a large German IDDM dataset

1986 • 40 citations

Genetic heterogeneity of insulin-dependent (type I) diabetes mellitus: evidence from a study of extended haplotypes.

1984 • 36 citations

HLA and autoimmune endocrine disease 1985.

1986 • 36 citations

HLA-DR4 in insulin-dependent diabetic parents and their diabetic offspring: a clue to dominant inheritance.

1986 • 35 citations

Hypothesis: The Frequencies of Juvenile Diabetes in American Blacks and Caucasians Are Consistent with Dominant Inheritance

1980 • 30 citations

Juvenile diabetes mellitus and the HLA system.

1979 • 30 citations

DR4 and susceptibility to type I diabetes mellitus: discrimination of high risk and low risk DR4 haplotypes on the basis of TA10 typing

1986 • 25 citations

DR2+ haplotypes in insulin-dependent diabetes: Analysis of DNA restriction fragment length polymorphisms

1986 • 25 citations

Heterogeneity of insulin‐dependent diabetes–new evidence

1982 • 24 citations

A Particular Subset of HLA-DR4 Accounts for All or Most of the DR4 Association in Type I Diabetes

1985 • 23 citations

A minor subset of HLA-DR3 haplotypes is preferentially increased in Type 1 (insulin-dependent) diabetes

1985 • 21 citations

Population genetic analyses of insulin dependent diabetes mellitus using HLA allele frequencies

1983 • 20 citations

Class III alleles and high-risk MHC haplotypes in type I diabetes mellitus, Graves' disease and Hashimoto's thyroiditis.

1986 • 17 citations

Response: Racial Differences in Juvenile-type Diabetes Are Consistent with More Than One Mode of Inheritance

1980 • 16 citations

Human Lymphocyte Antigen DR Types in Relation to Early Clinical Manifestations in Diabetic Children

1984 • 15 citations

Genetic analysis workshop IV: Insulin dependent diabetes mellitus - summary

1986 • 14 citations

HLA antigens and complotypes in insulin-dependent diabetes mellitus

1986 • 14 citations

HLA and IDDM predisposition: New aspects

1986 • 12 citations

A combined segregation and linkage analysis of insulin-dependent diabetes mellitus

1986 • 12 citations

Discrimination between genetic models for insulin dependent diabetes mellitus

1986 • 10 citations

Radioimmunoassay typing gives a more precise definition of the HLA association of Type I (insulin-dependent) diabetes

1986 • 8 citations

HLA-DR antigens in insulin-dependent diabetes.

1981 • 7 citations