Contribution of Protein Kinase C to the Phosphorylation of Rhodopsin in Intact Retinas

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

Visual excitation and recovery

1991 • 530 citations

THE MOLAR EXTINCTION OF RHODOPSIN

1953 • 444 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

G protein—coupled receptor kinases

1993 • 434 citations

Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin

1993 • 401 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Inhibition of protein kinase C by calphostin C is light-dependent

1991 • 374 citations

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

1992 • 330 citations

Transduction mechanisms of vertebrate and invertebrate photoreceptors.

1994 • 286 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Signal flow in visual transduction

1992 • 238 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

1991 • 175 citations

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

1994 • 159 citations

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.

1986 • 150 citations

Mass spectrometric identification of phosphorylation sites in bleached bovine rhodopsin

1993 • 140 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

Phosphorylation sites in bovine rhodopsin

1993 • 129 citations

Phosphatidylinositol 4,5-bisphosphate: Light-mediated breakdown in the vertebrate retina

1984 • 129 citations

Light-dependent phosphorylation of rhodopsin in living frogs

1974 • 128 citations

Calcium modulation of inositol 1,4,5-trisphosphate-induced calcium release from neuroblastoma x glioma hybrid (NG108-15) microsomes.

1986 • 121 citations

The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate

1991 • 110 citations

Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP

1985 • 102 citations

Calcium Modulation of Bovine Photoreceptor Guanylate Cyclase

1996 • 100 citations

Involvement of protein kinase C in the phosphorylation of rhodopsin.

1991 • 98 citations

Rhodopsin Kinase Inhibition by Recoverin

1995 • 97 citations

Control of Rhodopsin Multiple Phosphorylation

1994 • 95 citations

Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C

1992 • 94 citations

Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors.

1993 • 90 citations

Light-mediated breakdown of phosphatidylinositol-4,5-bisphosphate in isolated rod outer segments of frog photoreceptor

1985 • 90 citations

Functional effect of phosphorylation of the photoreceptor phosphodiesterase inhibitory subunit by protein kinase C

1994 • 83 citations

Phosphorylation of rhodopsin by protein kinase C in vitro.

1986 • 81 citations

Endogenous phosphorylation of retinal photoreceptor outer segment proteins by calcium phospholipid-dependent protein kinase

1984 • 65 citations

Stimulation of protein phosphatase-1 activity by phorbol esters. Evaluation of the regulatory role of protein kinase C in insulin action

1994 • 54 citations

Deletion analysis of protein kinase c inactivation by calphostin C

1995 • 52 citations

Phosphatidylinositol synthesis and phosphorylation are enhanced by light in rat retinas.

1983 • 49 citations

Subspecies of arrestin from bovine retina

1990 • 40 citations

Seven-helix receptors

1991 • 39 citations

Kinetics and Localization of the Phosphorylation of Rhodopsin by Protein Kinase C

1995 • 31 citations

Does protein kinase C play a role in rhodopsin desensitization?

1993 • 27 citations

Rapid purification and characterization of protein kinase C from bovine retinal rod outer segments

1991 • 26 citations

Immunochemical evidence for the light-regulated modulation of phosphatidylinositol-4,5-bisphosphate in rat photoreceptor cells.

1987 • 24 citations

Protein kinase C in rod outer segments: effects of phosphorylation of the phosphodiesterase inhibitory subunit

1996 • 17 citations

Preparation and Characterization of Protein Kinase C from Rod Outer Segments

1993 • 10 citations