Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

1996 • 333 citations

The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila

1996 • 331 citations

The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.

1995 • 329 citations

A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

1990 • 313 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.

1988 • 277 citations

Oncogenes and cell death

1994 • 266 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo

1991 • 212 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

1994 • 205 citations

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

1996 • 171 citations

Insulin Receptor Signaling Is Augmented by Antisense Inhibition of the Protein Tyrosine Phosphatase LAR

1995 • 160 citations

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

1995 • 154 citations

P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

1994 • 147 citations

The Transmembrane Protein-tyrosine Phosphatase LAR Modulates Signaling by Multiple Receptor Tyrosine Kinases

1996 • 130 citations

Suppression of Interleukin-1β-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor

1996 • 121 citations

Functional Association between the Insulin Receptor and the Transmembrane Protein-tyrosine Phosphatase LAR in Intact Cells

1997 • 100 citations

Molecular control of life and death

1995 • 95 citations

Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines.

1993 • 88 citations

Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.

1996 • 75 citations

Protein Tyrosine Phosphatases and the Control of Cellular Signaling Responses

1996 • 69 citations

Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression.

1993 • 68 citations

The N-terminal and C-terminal domains of a receptor tyrosine phosphatase are associated by non-covalent linkage.

1992 • 61 citations

Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation.

1996 • 52 citations

Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells

1996 • 49 citations

Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide

1996 • 45 citations

Effect of tumor necrosis factor-α on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein-tyrosine phosphatases

1997 • 42 citations

Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR

1996 • 35 citations

mRNA Expression of Two Transmembrane Protein Tyrosine Phosphatases Is Modulated by Growth Factors and Growth Arrest in 3T3 Fibroblasts

1995 • 16 citations

Apoptosis in hematopoietic cells is associated with an extensive decrease in cellular phosphotyrosine content that can be inhibited by the tyrosine phosphatase antagonist pervanadate

1996 • 15 citations

Consequences of altered oncogene expression in rodent cells

1985 • 14 citations

Two closely related receptor‐type tyrosine phosphatases are differentially expressed during rat lung development

1995 • 11 citations

The control of cell death in the early chick embryo wing bud

1997 • 3 citations