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Development of functionally selective agonists as novel therapeutic agents

Data up to Jan 2025

Published2006
Citations26
References36

Total Citations Per Year

Abstract

References (36)

A MODIFICATION OF RECEPTOR THEORY

1956 • 1,126 citations

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

2004 • 1,111 citations

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 • 1,076 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

Advances in Drug Research

1964 • 615 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

2004 • 456 citations

Functional Dissociation of μ Opioid Receptor Signaling and Endocytosis

1999 • 422 citations

Morphine-activated opioid receptors elude desensitization by β-arrestin

1998 • 374 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

Coupling ligand structure to specific conformational switches in the β2-adrenoceptor

2006 • 336 citations

Sequential Binding of Agonists to the β2 Adrenoceptor

2003 • 333 citations

Ligand-selective receptor conformations revisited: the promise and the problem

2003 • 319 citations

New Concepts in Drug Discovery: Collateral Efficacy and Permissive Antagonism

2005 • 313 citations

Constitutive Activity of the Serotonin2C Receptor InhibitsIn VivoDopamine Release in the Rat Striatum and Nucleus Accumbens

2004 • 301 citations

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

2001 • 281 citations

Multiple Signaling States of G-Protein-Coupled Receptors

2005 • 237 citations

μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

1997 • 218 citations

Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

2005 • 216 citations

A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

1965 • 207 citations

Aripiprazole has Functionally Selective Actions at Dopamine D2 Receptor-Mediated Signaling Pathways

2006 • 188 citations

Protean agonism at histamine H 3 receptors in vitro and in vivo

2003 • 145 citations

RNA‐editing of the 5‐HT2C receptor alters agonist‐receptor‐effector coupling specificity

2001 • 139 citations

Multiple mechanisms of serotonergic signal transduction

1987 • 133 citations

The elusive nature of intrinsic efficacy

1998 • 102 citations

Predicting therapeutic value in the lead optimization phase of drug discovery

2003 • 99 citations

G protein‐coupled receptors: a count of 1001 conformations

2005 • 94 citations

Agonist-induced modulation of inverse agonist efficacy at the beta 2-adrenergic receptor.

1996 • 90 citations

Protean agonism at alpha2A-adrenoceptors.

1998 • 71 citations

Distinct Differences Between Morphine‐ and [<scp>d</scp>‐Ala2,N‐MePhe4,Gly‐ol5]‐Enkephalin‐ μ‐Opioid Receptor Complexes Demonstrated by Cyclic AMP‐Dependent Protein Kinase Phosphorylation

1998 • 67 citations

Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.

1998 • 64 citations

Rapid Desensitization of the Serotonin2C Receptor System: Effector Pathway and Agonist Dependence

2002 • 61 citations

Chemokine receptors — the new frontier for AIDS research

1996 • 54 citations

Evidence for protean agonism of RX 831003 at α2A-adrenoceptors by co-expression with different Gα protein subunits

2002 • 23 citations

An evaluation of the ability of a series of full alpha-1 adrenoceptor agonists to release internal calcium in venous smooth muscle.

1985 • 19 citations

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Development of functionally selective agonists as novel therapeutic agents (2006) – Drug Discovery Today Therapeutic Strategies | Metascience Observatory Explorer